NK cells are activated and primed for skin-homing during acute dengue virus infection in humans

Here, Zimmer et al. analyze the natural killer (NK) cell response in a patient cohort with acute dengue virus infection showing early NK cell activation and proliferation, and the data suggest that NK cell proliferation depends on IL-18 signaling, and that responding NK cells have a skin-homing phen...

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Main Authors:	Christine L. Zimmer, Martin Cornillet, Carles Solà-Riera, Ka-Wai Cheung, Martin A. Ivarsson, Mei Qiu Lim, Nicole Marquardt, Yee-Sin Leo, David Chien Lye, Jonas Klingström, Paul A. MacAry, Hans-Gustaf Ljunggren, Laura Rivino, Niklas K. Björkström
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11878-3

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spelling	doaj-9e5b6fae44fb48c5a13eee33e02cd24b2021-05-11T11:47:10ZengNature Publishing GroupNature Communications2041-17232019-08-0110111510.1038/s41467-019-11878-3NK cells are activated and primed for skin-homing during acute dengue virus infection in humansChristine L. Zimmer0Martin Cornillet1Carles Solà-Riera2Ka-Wai Cheung3Martin A. Ivarsson4Mei Qiu Lim5Nicole Marquardt6Yee-Sin Leo7David Chien Lye8Jonas Klingström9Paul A. MacAry10Hans-Gustaf Ljunggren11Laura Rivino12Niklas K. Björkström13Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University HospitalDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University HospitalDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University HospitalProgramme in Emerging Infectious Diseases, DUKE-NUS Medical SchoolDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University HospitalProgramme in Emerging Infectious Diseases, DUKE-NUS Medical SchoolDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University HospitalInstitute of Infectious Diseases and Epidemiology, Communicable Disease Centre, Tan Tock Seng HospitalInstitute of Infectious Diseases and Epidemiology, Communicable Disease Centre, Tan Tock Seng HospitalDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University HospitalImmunology Programme, Life Science Institute and Department of Microbiology and Immunology, National University of SingaporeDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University HospitalProgramme in Emerging Infectious Diseases, DUKE-NUS Medical SchoolDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University HospitalHere, Zimmer et al. analyze the natural killer (NK) cell response in a patient cohort with acute dengue virus infection showing early NK cell activation and proliferation, and the data suggest that NK cell proliferation depends on IL-18 signaling, and that responding NK cells have a skin-homing phenotype.https://doi.org/10.1038/s41467-019-11878-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Christine L. Zimmer Martin Cornillet Carles Solà-Riera Ka-Wai Cheung Martin A. Ivarsson Mei Qiu Lim Nicole Marquardt Yee-Sin Leo David Chien Lye Jonas Klingström Paul A. MacAry Hans-Gustaf Ljunggren Laura Rivino Niklas K. Björkström
spellingShingle	Christine L. Zimmer Martin Cornillet Carles Solà-Riera Ka-Wai Cheung Martin A. Ivarsson Mei Qiu Lim Nicole Marquardt Yee-Sin Leo David Chien Lye Jonas Klingström Paul A. MacAry Hans-Gustaf Ljunggren Laura Rivino Niklas K. Björkström NK cells are activated and primed for skin-homing during acute dengue virus infection in humans Nature Communications
author_facet	Christine L. Zimmer Martin Cornillet Carles Solà-Riera Ka-Wai Cheung Martin A. Ivarsson Mei Qiu Lim Nicole Marquardt Yee-Sin Leo David Chien Lye Jonas Klingström Paul A. MacAry Hans-Gustaf Ljunggren Laura Rivino Niklas K. Björkström
author_sort	Christine L. Zimmer
title	NK cells are activated and primed for skin-homing during acute dengue virus infection in humans
title_short	NK cells are activated and primed for skin-homing during acute dengue virus infection in humans
title_full	NK cells are activated and primed for skin-homing during acute dengue virus infection in humans
title_fullStr	NK cells are activated and primed for skin-homing during acute dengue virus infection in humans
title_full_unstemmed	NK cells are activated and primed for skin-homing during acute dengue virus infection in humans
title_sort	nk cells are activated and primed for skin-homing during acute dengue virus infection in humans
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-08-01
description	Here, Zimmer et al. analyze the natural killer (NK) cell response in a patient cohort with acute dengue virus infection showing early NK cell activation and proliferation, and the data suggest that NK cell proliferation depends on IL-18 signaling, and that responding NK cells have a skin-homing phenotype.
url	https://doi.org/10.1038/s41467-019-11878-3
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NK cells are activated and primed for skin-homing during acute dengue virus infection in humans

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