Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective
In Covid-19, systemic disturbances may progress due to development of cytokine storm and dysregulation of and plasma osmolarility due to high release of pro-inflammatory cytokines and neuro-hormonal disorders. Arginine vasopressin (AVP) which is involve in the regulation of body osmotic system, body...
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doaj-9e5e5e7c57c34a939dd81cd5f47c2ab22021-10-11T04:15:09ZengElsevierBiomedicine & Pharmacotherapy0753-33222021-11-01143112193Arginine vasopressin and pathophysiology of COVID-19: An innovative perspectiveHayder M. Al-kuraishy0Ali I. Al-Gareeb1Safaa Qusti2Eida M. Alshammari3Francis O. Atanu4Gaber El-Saber Batiha5Department of Clinical Pharmacology and Medicine, College of Medicine, ALmustansiriyia University, Baghdad, IraqDepartment of Clinical Pharmacology and Medicine, College of Medicine, ALmustansiriyia University, Baghdad, IraqDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi ArabiaDepartment of Chemistry, College of Sciences, University of Ha’il, Ha’il, Saudi ArabiaDepartment of Biochemistry, Faculty of Natural Sciences, Kogi State University, P.M.B. 1008 Anyigba, NigeriaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, AlBeheira, Egypt; Corresponding author.In Covid-19, systemic disturbances may progress due to development of cytokine storm and dysregulation of and plasma osmolarility due to high release of pro-inflammatory cytokines and neuro-hormonal disorders. Arginine vasopressin (AVP) which is involve in the regulation of body osmotic system, body water content, blood pressure and plasma volume, that are highly disturbed in Covid-19 and linked with poor clinical outcomes. Therefore, this present study aimed to find the potential association between AVP serum level and inflammatory disorders in Covid-19. It has been observed by different recent studies that physiological response due to fever, pain, hypovolemia, dehydration, and psychological stress is characterized by activation release of AVP to counter-balance high blood viscosity in Covid-19 patients. In addition, activated immune cells mainly T and B lymphocytes and released pro-inflammatory cytokines stimulate discharge of stored AVP from immune cells, which in a vicious cycle trigger release of pro-inflammatory cytokines. Vasopressin receptor antagonists have antiviral and anti-inflammatory effects that may inhibit AVP-induced hyponatremia and release of pro-inflammatory cytokines in Covid-19. In conclusion, release of AVP from hypothalamus is augmented in Covid-19 due to stress, high pro-inflammatory cytokines, high circulating AngII and inhibition of GABAergic neurons. In turn, high AVP level leads to induction of hyponatremia, inflammatory disorders, and development of complications in Covid-19 by activation of NF-κB and NLRP3 inflammasome with release of pro-inflammatory cytokines. Therefore, AVP antagonists might be novel potential therapeutic modality in treating Covid-19 through mitigation of AVP-mediated inflammatory disorders and hyponatremia.http://www.sciencedirect.com/science/article/pii/S075333222100977XCovid-19Arginine vasopressinHyponatremia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hayder M. Al-kuraishy Ali I. Al-Gareeb Safaa Qusti Eida M. Alshammari Francis O. Atanu Gaber El-Saber Batiha |
spellingShingle |
Hayder M. Al-kuraishy Ali I. Al-Gareeb Safaa Qusti Eida M. Alshammari Francis O. Atanu Gaber El-Saber Batiha Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective Biomedicine & Pharmacotherapy Covid-19 Arginine vasopressin Hyponatremia |
author_facet |
Hayder M. Al-kuraishy Ali I. Al-Gareeb Safaa Qusti Eida M. Alshammari Francis O. Atanu Gaber El-Saber Batiha |
author_sort |
Hayder M. Al-kuraishy |
title |
Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective |
title_short |
Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective |
title_full |
Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective |
title_fullStr |
Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective |
title_full_unstemmed |
Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective |
title_sort |
arginine vasopressin and pathophysiology of covid-19: an innovative perspective |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2021-11-01 |
description |
In Covid-19, systemic disturbances may progress due to development of cytokine storm and dysregulation of and plasma osmolarility due to high release of pro-inflammatory cytokines and neuro-hormonal disorders. Arginine vasopressin (AVP) which is involve in the regulation of body osmotic system, body water content, blood pressure and plasma volume, that are highly disturbed in Covid-19 and linked with poor clinical outcomes. Therefore, this present study aimed to find the potential association between AVP serum level and inflammatory disorders in Covid-19. It has been observed by different recent studies that physiological response due to fever, pain, hypovolemia, dehydration, and psychological stress is characterized by activation release of AVP to counter-balance high blood viscosity in Covid-19 patients. In addition, activated immune cells mainly T and B lymphocytes and released pro-inflammatory cytokines stimulate discharge of stored AVP from immune cells, which in a vicious cycle trigger release of pro-inflammatory cytokines. Vasopressin receptor antagonists have antiviral and anti-inflammatory effects that may inhibit AVP-induced hyponatremia and release of pro-inflammatory cytokines in Covid-19. In conclusion, release of AVP from hypothalamus is augmented in Covid-19 due to stress, high pro-inflammatory cytokines, high circulating AngII and inhibition of GABAergic neurons. In turn, high AVP level leads to induction of hyponatremia, inflammatory disorders, and development of complications in Covid-19 by activation of NF-κB and NLRP3 inflammasome with release of pro-inflammatory cytokines. Therefore, AVP antagonists might be novel potential therapeutic modality in treating Covid-19 through mitigation of AVP-mediated inflammatory disorders and hyponatremia. |
topic |
Covid-19 Arginine vasopressin Hyponatremia |
url |
http://www.sciencedirect.com/science/article/pii/S075333222100977X |
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