P116 Post-stroke White Coat Hypertension/Effect is Associated with Greater Arterial Stiffness
Objective: White coat hypertension/effect (WCH/E) describes an elevated clinic blood pressure (BP) with normal daytime ambulatory BP (ABPM) values. It is not clear whether WCH/E is associated with adverse vascular risk. This study aimed to determine the relationship between WCH/E and arterial stiffn...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Atlantis Press
2020-02-01
|
Series: | Artery Research |
Online Access: | https://www.atlantis-press.com/article/125934588/view |
id |
doaj-9e60030d47e341b18e2c5c7d609ffac4 |
---|---|
record_format |
Article |
spelling |
doaj-9e60030d47e341b18e2c5c7d609ffac42020-11-25T03:30:14ZengAtlantis PressArtery Research 1876-44012020-02-0125110.2991/artres.k.191224.142P116 Post-stroke White Coat Hypertension/Effect is Associated with Greater Arterial StiffnessFran KirkhamA SaundersGN NurediniE DrazichPhilip RankinE BuntingK AliM OkorieC RajkumarObjective: White coat hypertension/effect (WCH/E) describes an elevated clinic blood pressure (BP) with normal daytime ambulatory BP (ABPM) values. It is not clear whether WCH/E is associated with adverse vascular risk. This study aimed to determine the relationship between WCH/E and arterial stiffness in a cohort of patients who had a transient ischaemic attack (TIA) or lacunar stroke (LS). Design and Method: The Arterial Stiffness In Lacunar Stroke and TIA (ASIST) study recruited 96 patients, aged over 40 years old, with a confirmed diagnosis of TIA or LS in the preceding 14 days. Patients were grouped by BP. Thirty-four patients were excluded (n = 6 declined ABPM, n = 3 masked hypertension and n = 25 sustained hypertension). Thirty-two patients with normal BP (clinic BP < 140/90 mmHg and day-time ABPM < 135/85 mmHg), and 30 patients with WCH/E (clinic BP > 140/90 mmHg and day-time ABPM < 135/85 mmHg) were recruited. Arterial stiffness was measured using carotid-femoral pulse wave velocity (PWV), (Complior®, ALAM Medical) and carotid-ankle vascular index (CAVI), (VaSera VS-1500 N®, Fukuda Denshi). Results: Compared to patients with normal BP, patients with WCH/E were older, had a higher body mass index (BMI) and higher arterial stiffness measured by CAVI (10.3 ± 1.3 vs 9.4 ± 1.7, p = 0.027), and PWV (11.9 ± 3.0 vs 9.6 ± 2.3 ms−1, p = 0.002). The WCH/E cohort had more lacunar strokes (p = 0.039). Conclusion: In this population of post-stroke patients, those with WCH/E had greater arterial stiffness and a higher prevalence of lacunar stroke. These results suggest that WCH/E is associated with adverse cardiovascular risk. Normotension (N = 32) WCH/E (N = 30) Statistical significance Male, n (%) 21(66) 22(73) 0.511 Age (years) 69.9 ± 11.5 75.7 ± 9.3 0.033 BMI (kg/m2) 25 ± 4 28 ± 4 0.014 Anti-hypertensive use, n (%) 19(59) 23(77) 0.146 Clinic systolic BP (mmHg) 125 ± 9 155 ± 13 <0.001 Clinic diastolic BP (mmHg) 75 ± 7 81 ± 8 0.003 Daytime systolic ABPM (mmHg) 114 ± 10 121 ± 10 0.007 Daytime diastolic ABPM (mmHg) 73 ± 7 72 ± 7 0.586 CAVI 9.4 ± 1.7 10.3 ± 1.3 0.027 PWV (ms−1) 9.6 ± 2.3 11.9 ± 3.0 0.002 Stroke type TIA, n (%) 25(78) 16(53) 0.039 Lacunar, n (%) 7(22) 14(47) Data expressed as mean ± standard deviation or number (percentage). Significance determined by t-test. Chi-squared used for anti-hypertensive use, gender and stroke type.https://www.atlantis-press.com/article/125934588/view |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fran Kirkham A Saunders GN Nuredini E Drazich Philip Rankin E Bunting K Ali M Okorie C Rajkumar |
spellingShingle |
Fran Kirkham A Saunders GN Nuredini E Drazich Philip Rankin E Bunting K Ali M Okorie C Rajkumar P116 Post-stroke White Coat Hypertension/Effect is Associated with Greater Arterial Stiffness Artery Research |
author_facet |
Fran Kirkham A Saunders GN Nuredini E Drazich Philip Rankin E Bunting K Ali M Okorie C Rajkumar |
author_sort |
Fran Kirkham |
title |
P116 Post-stroke White Coat Hypertension/Effect is Associated with Greater Arterial Stiffness |
title_short |
P116 Post-stroke White Coat Hypertension/Effect is Associated with Greater Arterial Stiffness |
title_full |
P116 Post-stroke White Coat Hypertension/Effect is Associated with Greater Arterial Stiffness |
title_fullStr |
P116 Post-stroke White Coat Hypertension/Effect is Associated with Greater Arterial Stiffness |
title_full_unstemmed |
P116 Post-stroke White Coat Hypertension/Effect is Associated with Greater Arterial Stiffness |
title_sort |
p116 post-stroke white coat hypertension/effect is associated with greater arterial stiffness |
publisher |
Atlantis Press |
series |
Artery Research |
issn |
1876-4401 |
publishDate |
2020-02-01 |
description |
Objective: White coat hypertension/effect (WCH/E) describes an elevated clinic blood pressure (BP) with normal daytime ambulatory BP (ABPM) values. It is not clear whether WCH/E is associated with adverse vascular risk. This study aimed to determine the relationship between WCH/E and arterial stiffness in a cohort of patients who had a transient ischaemic attack (TIA) or lacunar stroke (LS).
Design and Method: The Arterial Stiffness In Lacunar Stroke and TIA (ASIST) study recruited 96 patients, aged over 40 years old, with a confirmed diagnosis of TIA or LS in the preceding 14 days. Patients were grouped by BP. Thirty-four patients were excluded (n = 6 declined ABPM, n = 3 masked hypertension and n = 25 sustained hypertension). Thirty-two patients with normal BP (clinic BP < 140/90 mmHg and day-time ABPM < 135/85 mmHg), and 30 patients with WCH/E (clinic BP > 140/90 mmHg and day-time ABPM < 135/85 mmHg) were recruited. Arterial stiffness was measured using carotid-femoral pulse wave velocity (PWV), (Complior®, ALAM Medical) and carotid-ankle vascular index (CAVI), (VaSera VS-1500 N®, Fukuda Denshi).
Results: Compared to patients with normal BP, patients with WCH/E were older, had a higher body mass index (BMI) and higher arterial stiffness measured by CAVI (10.3 ± 1.3 vs 9.4 ± 1.7, p = 0.027), and PWV (11.9 ± 3.0 vs 9.6 ± 2.3 ms−1, p = 0.002). The WCH/E cohort had more lacunar strokes (p = 0.039).
Conclusion: In this population of post-stroke patients, those with WCH/E had greater arterial stiffness and a higher prevalence of lacunar stroke. These results suggest that WCH/E is associated with adverse cardiovascular risk.
Normotension (N = 32)
WCH/E (N = 30)
Statistical significance
Male, n (%)
21(66)
22(73)
0.511
Age (years)
69.9 ± 11.5
75.7 ± 9.3
0.033
BMI (kg/m2)
25 ± 4
28 ± 4
0.014
Anti-hypertensive use, n (%)
19(59)
23(77)
0.146
Clinic systolic BP (mmHg)
125 ± 9
155 ± 13
<0.001
Clinic diastolic BP (mmHg)
75 ± 7
81 ± 8
0.003
Daytime systolic ABPM (mmHg)
114 ± 10
121 ± 10
0.007
Daytime diastolic ABPM (mmHg)
73 ± 7
72 ± 7
0.586
CAVI
9.4 ± 1.7
10.3 ± 1.3
0.027
PWV (ms−1)
9.6 ± 2.3
11.9 ± 3.0
0.002
Stroke type
TIA, n (%)
25(78)
16(53)
0.039
Lacunar, n (%)
7(22)
14(47)
Data expressed as mean ± standard deviation or number (percentage). Significance determined by t-test. Chi-squared used for anti-hypertensive use, gender and stroke type. |
url |
https://www.atlantis-press.com/article/125934588/view |
work_keys_str_mv |
AT frankirkham p116poststrokewhitecoathypertensioneffectisassociatedwithgreaterarterialstiffness AT asaunders p116poststrokewhitecoathypertensioneffectisassociatedwithgreaterarterialstiffness AT gnnuredini p116poststrokewhitecoathypertensioneffectisassociatedwithgreaterarterialstiffness AT edrazich p116poststrokewhitecoathypertensioneffectisassociatedwithgreaterarterialstiffness AT philiprankin p116poststrokewhitecoathypertensioneffectisassociatedwithgreaterarterialstiffness AT ebunting p116poststrokewhitecoathypertensioneffectisassociatedwithgreaterarterialstiffness AT kali p116poststrokewhitecoathypertensioneffectisassociatedwithgreaterarterialstiffness AT mokorie p116poststrokewhitecoathypertensioneffectisassociatedwithgreaterarterialstiffness AT crajkumar p116poststrokewhitecoathypertensioneffectisassociatedwithgreaterarterialstiffness |
_version_ |
1724576747959091200 |