Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia.

Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia.

Hypoxia and pressure-overload induce heme oxygenase-1 (HO-1) in cardiomyocytes and vascular smooth muscle cells (VSMCs). HO-1(-/-) mice exposed to chronic hypoxia develop pulmonary arterial hypertension (PAH) with exaggerated right ventricular (RV) injury consisting of dilation, fibrosis, and mural...

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Bibliographic Details
Main Authors: Sally H Vitali, S Alex Mitsialis, Olin D Liang, Xiaoli Liu, Angeles Fernandez-Gonzalez, Helen Christou, Xinqi Wu, Francis X McGowan, Stella Kourembanas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2694354?pdf=render

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