Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model
Inflammation of the synovium and joint capsule is a main driver of pain in an osteoarthritic (OA) joint. Triamcinolone acetonide (TAA) is a classical corticosteroid that reduces synovitis and alleviates pain, albeit transiently. Biomaterial-based local TAA release may prolong the suppression of pain...
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doaj-9e7b74ab86124f0b86ca8010f97063b22020-11-25T01:35:17ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642019-01-0126122623610.1080/10717544.2019.15686251568625Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis modelImke Rudnik-Jansen0Karin Schrijver1Nina Woike2Anna Tellegen3Sabine Versteeg4Pieter Emans5George Mihov6Jens Thies7Niels Eijkelkamp8Marianna Tryfonidou9Laura Creemers10University Medical Center UtrechtUniversity Medical Center UtrechtDSM Biomedical B.VUtrecht UniversityUniversity Medical Center Utrecht, Utrecht UniversityMaastricht University Medical Center UtrechtDSM Biomedical B.VDSM Biomedical B.VUniversity Medical Center Utrecht, Utrecht UniversityUtrecht UniversityUniversity Medical Center UtrechtInflammation of the synovium and joint capsule is a main driver of pain in an osteoarthritic (OA) joint. Triamcinolone acetonide (TAA) is a classical corticosteroid that reduces synovitis and alleviates pain, albeit transiently. Biomaterial-based local TAA release may prolong the suppression of pain without the need for multiple injections. Polylactic-co-glycolic acid (PLGA) formulations of TAA prolong OA pain relief to a limited extent. A novel polyesteramide (PEA) microsphere platform allows for extended release in the OA joint for over 3 months. To evaluate their effect on pain and inflammation, TAA-loaded microspheres were intra-articularly delivered to the knee joint in a rat model of acute arthritis induced by intra-articular injection of streptococcal cell wall peptidoglycan-polysaccharide (PGPS) and subsequent flare-ups by intravenous PGPS injections. PEA-loaded microspheres were benchmarked with TAA-loaded PLGA microspheres and bolus TAA injection. TAA treatments were injected intra-articularly before the first induced flare-up. TAA-loaded PEA and PLGA microspheres reduced joint swelling and signs of pain-like behavior over the entire study period, as assessed by weight bearing and referred mechanical hypersensitivity, whereas bolus suspension was effective for a shorter time period. TAA-loaded PEA microspheres reduced lameness to a greater extent than TAA-loaded PLGA microspheres. In conclusion, a single intra-articular injection of TAA-loaded PEA microspheres reduced joint swelling and induced longer pain relief compared to bolus injection. Hence relief of inflammation and pain by PEA-based delivery of TAA may prove to be effective and durable.http://dx.doi.org/10.1080/10717544.2019.1568625arthritismicrospherespolyesteramidepolylactic-co-glycolic acidsynovitistriamcinolone acetonide |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Imke Rudnik-Jansen Karin Schrijver Nina Woike Anna Tellegen Sabine Versteeg Pieter Emans George Mihov Jens Thies Niels Eijkelkamp Marianna Tryfonidou Laura Creemers |
spellingShingle |
Imke Rudnik-Jansen Karin Schrijver Nina Woike Anna Tellegen Sabine Versteeg Pieter Emans George Mihov Jens Thies Niels Eijkelkamp Marianna Tryfonidou Laura Creemers Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model Drug Delivery arthritis microspheres polyesteramide polylactic-co-glycolic acid synovitis triamcinolone acetonide |
author_facet |
Imke Rudnik-Jansen Karin Schrijver Nina Woike Anna Tellegen Sabine Versteeg Pieter Emans George Mihov Jens Thies Niels Eijkelkamp Marianna Tryfonidou Laura Creemers |
author_sort |
Imke Rudnik-Jansen |
title |
Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model |
title_short |
Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model |
title_full |
Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model |
title_fullStr |
Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model |
title_full_unstemmed |
Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model |
title_sort |
intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model |
publisher |
Taylor & Francis Group |
series |
Drug Delivery |
issn |
1071-7544 1521-0464 |
publishDate |
2019-01-01 |
description |
Inflammation of the synovium and joint capsule is a main driver of pain in an osteoarthritic (OA) joint. Triamcinolone acetonide (TAA) is a classical corticosteroid that reduces synovitis and alleviates pain, albeit transiently. Biomaterial-based local TAA release may prolong the suppression of pain without the need for multiple injections. Polylactic-co-glycolic acid (PLGA) formulations of TAA prolong OA pain relief to a limited extent. A novel polyesteramide (PEA) microsphere platform allows for extended release in the OA joint for over 3 months. To evaluate their effect on pain and inflammation, TAA-loaded microspheres were intra-articularly delivered to the knee joint in a rat model of acute arthritis induced by intra-articular injection of streptococcal cell wall peptidoglycan-polysaccharide (PGPS) and subsequent flare-ups by intravenous PGPS injections. PEA-loaded microspheres were benchmarked with TAA-loaded PLGA microspheres and bolus TAA injection. TAA treatments were injected intra-articularly before the first induced flare-up. TAA-loaded PEA and PLGA microspheres reduced joint swelling and signs of pain-like behavior over the entire study period, as assessed by weight bearing and referred mechanical hypersensitivity, whereas bolus suspension was effective for a shorter time period. TAA-loaded PEA microspheres reduced lameness to a greater extent than TAA-loaded PLGA microspheres. In conclusion, a single intra-articular injection of TAA-loaded PEA microspheres reduced joint swelling and induced longer pain relief compared to bolus injection. Hence relief of inflammation and pain by PEA-based delivery of TAA may prove to be effective and durable. |
topic |
arthritis microspheres polyesteramide polylactic-co-glycolic acid synovitis triamcinolone acetonide |
url |
http://dx.doi.org/10.1080/10717544.2019.1568625 |
work_keys_str_mv |
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