Intelligent Bimetallic Nanoagents as Reactive Oxygen Species Initiator System for Effective Combination Phototherapy
Phototherapy is a promising oncotherapy method. However, there are various factors greatly restricted phototherapy development, including poor tumor-specific accumulation, the hypoxia in solid tumor, and the systemic phototoxicity of photosensitizer. Herein, a tumor microenvironment (TME)-responsive...
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Frontiers Media S.A.
2020-05-01
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Series: | Frontiers in Bioengineering and Biotechnology |
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Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2020.00423/full |
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doaj-9e82a8c3356f4f82a570fdfc68fa149a |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hongfeng Li Hongfeng Li Ying Li Ying Li Jingjing Xiang Jingjing Xiang Xing Yang Xing Yang Chunbing Li Chuangjun Liu Qi Zhao Lihua Zhou Ping Gong Ping Gong Jiahao Huang |
spellingShingle |
Hongfeng Li Hongfeng Li Ying Li Ying Li Jingjing Xiang Jingjing Xiang Xing Yang Xing Yang Chunbing Li Chuangjun Liu Qi Zhao Lihua Zhou Ping Gong Ping Gong Jiahao Huang Intelligent Bimetallic Nanoagents as Reactive Oxygen Species Initiator System for Effective Combination Phototherapy Frontiers in Bioengineering and Biotechnology bimetallic nanoagents photosensitizers tumor microenvironment reactive oxygen species phototherapy |
author_facet |
Hongfeng Li Hongfeng Li Ying Li Ying Li Jingjing Xiang Jingjing Xiang Xing Yang Xing Yang Chunbing Li Chuangjun Liu Qi Zhao Lihua Zhou Ping Gong Ping Gong Jiahao Huang |
author_sort |
Hongfeng Li |
title |
Intelligent Bimetallic Nanoagents as Reactive Oxygen Species Initiator System for Effective Combination Phototherapy |
title_short |
Intelligent Bimetallic Nanoagents as Reactive Oxygen Species Initiator System for Effective Combination Phototherapy |
title_full |
Intelligent Bimetallic Nanoagents as Reactive Oxygen Species Initiator System for Effective Combination Phototherapy |
title_fullStr |
Intelligent Bimetallic Nanoagents as Reactive Oxygen Species Initiator System for Effective Combination Phototherapy |
title_full_unstemmed |
Intelligent Bimetallic Nanoagents as Reactive Oxygen Species Initiator System for Effective Combination Phototherapy |
title_sort |
intelligent bimetallic nanoagents as reactive oxygen species initiator system for effective combination phototherapy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Bioengineering and Biotechnology |
issn |
2296-4185 |
publishDate |
2020-05-01 |
description |
Phototherapy is a promising oncotherapy method. However, there are various factors greatly restricted phototherapy development, including poor tumor-specific accumulation, the hypoxia in solid tumor, and the systemic phototoxicity of photosensitizer. Herein, a tumor microenvironment (TME)-responsive intelligent bimetallic nanoagents (HSA-Pd-Fe-Ce6 NAs) composed of human serum albumin (HSA), palladium-iron (Pd-Fe) bimetallic particles, and chlorin e6 (Ce6) was designed for effective combination phototherapy. The Pd-Fe part in the HSA-Pd-Fe-Ce6 NAs would react with the endogenous hydrogen peroxide (H2O2) in an acidic ambiance within tumor to generate cytotoxic superoxide anion free radical through the “Fenton-like reaction.” H2O2, coupled with highly toxic singlet oxygen (1O2) caused by the Ce6 component under the irradiation of 660 nm laser, resulted in synergistic cancer therapy effects in hypoxia surroundings. Besides, this nanoagents could result in hyperpyrexia-induced cell apoptosis because of superior absorption performance in near-infrared wavelength window bringing about excellent photothermal conversion efficiency. The cell cytotoxicity results showed that the survival rate after treated by 40 μg mL–1 nanoagents was only 17%, which reveals that the HSA-Pd-Fe-Ce6 NAs had the advantage of efficient and controllable phototherapy. In short, it exhibited excellent hypoxia-resistant combination phototherapy efficacy in vitro. Therefore, the multifunctional nanoagents are powerful and provide a new avenue for effective combination phototherapy. |
topic |
bimetallic nanoagents photosensitizers tumor microenvironment reactive oxygen species phototherapy |
url |
https://www.frontiersin.org/article/10.3389/fbioe.2020.00423/full |
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doaj-9e82a8c3356f4f82a570fdfc68fa149a2020-11-25T02:09:34ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-05-01810.3389/fbioe.2020.00423532050Intelligent Bimetallic Nanoagents as Reactive Oxygen Species Initiator System for Effective Combination PhototherapyHongfeng Li0Hongfeng Li1Ying Li2Ying Li3Jingjing Xiang4Jingjing Xiang5Xing Yang6Xing Yang7Chunbing Li8Chuangjun Liu9Qi Zhao10Lihua Zhou11Ping Gong12Ping Gong13Jiahao Huang14Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, ChinaGuangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, ChinaGuangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, ChinaSchool of Materials Science and Engineering, Guilin University of Electronic Technology, Guilin, ChinaGuangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaGuangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaGuangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, ChinaGuangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, ChinaFaculty of Health Sciences, University of Macau, Macau, ChinaGuangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, ChinaGuangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, ChinaDongguan Key Laboratory of Drug Design and Formulation Technology, Key Laboratory for Nanomedicine, Guangdong Medical University, Dongguan, ChinaBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, ChinaPhototherapy is a promising oncotherapy method. However, there are various factors greatly restricted phototherapy development, including poor tumor-specific accumulation, the hypoxia in solid tumor, and the systemic phototoxicity of photosensitizer. Herein, a tumor microenvironment (TME)-responsive intelligent bimetallic nanoagents (HSA-Pd-Fe-Ce6 NAs) composed of human serum albumin (HSA), palladium-iron (Pd-Fe) bimetallic particles, and chlorin e6 (Ce6) was designed for effective combination phototherapy. The Pd-Fe part in the HSA-Pd-Fe-Ce6 NAs would react with the endogenous hydrogen peroxide (H2O2) in an acidic ambiance within tumor to generate cytotoxic superoxide anion free radical through the “Fenton-like reaction.” H2O2, coupled with highly toxic singlet oxygen (1O2) caused by the Ce6 component under the irradiation of 660 nm laser, resulted in synergistic cancer therapy effects in hypoxia surroundings. Besides, this nanoagents could result in hyperpyrexia-induced cell apoptosis because of superior absorption performance in near-infrared wavelength window bringing about excellent photothermal conversion efficiency. The cell cytotoxicity results showed that the survival rate after treated by 40 μg mL–1 nanoagents was only 17%, which reveals that the HSA-Pd-Fe-Ce6 NAs had the advantage of efficient and controllable phototherapy. In short, it exhibited excellent hypoxia-resistant combination phototherapy efficacy in vitro. Therefore, the multifunctional nanoagents are powerful and provide a new avenue for effective combination phototherapy.https://www.frontiersin.org/article/10.3389/fbioe.2020.00423/fullbimetallic nanoagentsphotosensitizerstumor microenvironmentreactive oxygen speciesphototherapy |