Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures
Diverse natural/artificial proteins have been used as building blocks to construct a variety of well-ordered nanoscale structures over the past couple of decades. Sophisticated protein self-assemblies have attracted great scientific interests due to their potential applications in disease diagnosis,...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-10-01
|
| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2020.587975/full |
| id |
doaj-9eb2ef1433b74be3a073973f6972ced9 |
|---|---|
| record_format |
Article |
| spelling |
doaj-9eb2ef1433b74be3a073973f6972ced92020-11-25T03:44:30ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462020-10-01810.3389/fchem.2020.587975587975Rationally Designed Protein Building Blocks for Programmable Hierarchical ArchitecturesWenbo Zhang0Shanshan Mo1Mingwei Liu2Lei Liu3Lanlan Yu4Chenxuan Wang5State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Department of Biophysics and Structural Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Department of Biophysics and Structural Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Department of Biophysics and Structural Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, United StatesState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Department of Biophysics and Structural Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Department of Biophysics and Structural Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDiverse natural/artificial proteins have been used as building blocks to construct a variety of well-ordered nanoscale structures over the past couple of decades. Sophisticated protein self-assemblies have attracted great scientific interests due to their potential applications in disease diagnosis, illness treatment, biomechanics, bio-optics and bio-electronics, etc. This review outlines recent efforts directed to the creation of structurally defined protein assemblies including one-dimensional (1D) strings/rings/tubules, two-dimensional (2D) planar sheets and three-dimensional (3D) polyhedral scaffolds. We elucidate various innovative strategies for manipulating proteins to self-assemble into desired architectures. The emergent applications of protein assemblies as versatile platforms in medicine and material science with improved performances have also been discussed.https://www.frontiersin.org/articles/10.3389/fchem.2020.587975/fullprotein self-assemblysupramolecular nanostructuresprotein-protein interactionsbioinspired materialshierarchical construction |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Wenbo Zhang Shanshan Mo Mingwei Liu Lei Liu Lanlan Yu Chenxuan Wang |
| spellingShingle |
Wenbo Zhang Shanshan Mo Mingwei Liu Lei Liu Lanlan Yu Chenxuan Wang Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures Frontiers in Chemistry protein self-assembly supramolecular nanostructures protein-protein interactions bioinspired materials hierarchical construction |
| author_facet |
Wenbo Zhang Shanshan Mo Mingwei Liu Lei Liu Lanlan Yu Chenxuan Wang |
| author_sort |
Wenbo Zhang |
| title |
Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures |
| title_short |
Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures |
| title_full |
Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures |
| title_fullStr |
Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures |
| title_full_unstemmed |
Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures |
| title_sort |
rationally designed protein building blocks for programmable hierarchical architectures |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Chemistry |
| issn |
2296-2646 |
| publishDate |
2020-10-01 |
| description |
Diverse natural/artificial proteins have been used as building blocks to construct a variety of well-ordered nanoscale structures over the past couple of decades. Sophisticated protein self-assemblies have attracted great scientific interests due to their potential applications in disease diagnosis, illness treatment, biomechanics, bio-optics and bio-electronics, etc. This review outlines recent efforts directed to the creation of structurally defined protein assemblies including one-dimensional (1D) strings/rings/tubules, two-dimensional (2D) planar sheets and three-dimensional (3D) polyhedral scaffolds. We elucidate various innovative strategies for manipulating proteins to self-assemble into desired architectures. The emergent applications of protein assemblies as versatile platforms in medicine and material science with improved performances have also been discussed. |
| topic |
protein self-assembly supramolecular nanostructures protein-protein interactions bioinspired materials hierarchical construction |
| url |
https://www.frontiersin.org/articles/10.3389/fchem.2020.587975/full |
| work_keys_str_mv |
AT wenbozhang rationallydesignedproteinbuildingblocksforprogrammablehierarchicalarchitectures AT shanshanmo rationallydesignedproteinbuildingblocksforprogrammablehierarchicalarchitectures AT mingweiliu rationallydesignedproteinbuildingblocksforprogrammablehierarchicalarchitectures AT leiliu rationallydesignedproteinbuildingblocksforprogrammablehierarchicalarchitectures AT lanlanyu rationallydesignedproteinbuildingblocksforprogrammablehierarchicalarchitectures AT chenxuanwang rationallydesignedproteinbuildingblocksforprogrammablehierarchicalarchitectures |
| _version_ |
1724514517025554432 |