Meningeal melanocytes in the mouse: Distribution and dependence on Mitf

Melanocytes are pigment producing cells derived from the neural crest. They are primarily found in the skin and hair follicles, but can also be found in other tissues including the eye, ear and heart. Here we describe the distribution of pigmented cells in C57BL/6J mouse meninges, the membranes that...

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Main Authors:	Stefan Arni Hafsteinsson Gudjohnsen, Diahann A. M. Atacho, Franck eGesbert, Graca eRaposo, Ilse eHurbain, Lionel eLarue, Eirikur eSteingrimsson, Petur Henry Petersen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2015-11-01
Series:	Frontiers in Neuroanatomy
Subjects:	Melanocytes Meninges Mouse MITF meningeal melanoma.
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00149/full

id	doaj-9ec09fc9f5ba4fcc81a7dea4c450a49d
record_format	Article
spelling	doaj-9ec09fc9f5ba4fcc81a7dea4c450a49d2020-11-24T23:05:05ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292015-11-01910.3389/fnana.2015.00149156485Meningeal melanocytes in the mouse: Distribution and dependence on MitfStefan Arni Hafsteinsson Gudjohnsen0Stefan Arni Hafsteinsson Gudjohnsen1Diahann A. M. Atacho2Diahann A. M. Atacho3Franck eGesbert4Graca eRaposo5Ilse eHurbain6Ilse eHurbain7Lionel eLarue8Eirikur eSteingrimsson9Petur Henry Petersen10University of IcelandUniversity of IcelandUniversity of IcelandUniversity of IcelandInstitut CurieInstitut CurieInstitut CurieCell and Tissue Imaging FacilityInstitut CurieUniversity of IcelandUniversity of IcelandMelanocytes are pigment producing cells derived from the neural crest. They are primarily found in the skin and hair follicles, but can also be found in other tissues including the eye, ear and heart. Here we describe the distribution of pigmented cells in C57BL/6J mouse meninges, the membranes that envelope the brain. These cells contain melanosomes of all four stages of development and they depend on MITF, the master regulator of melanocyte development, suggesting that they are bona-fide melanocytes. The location of these pigmented cells is consistent with the location of meningeal melanomas in humans and animal models.http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00149/fullMelanocytesMeningesMouseMITFmeningeal melanoma.
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Stefan Arni Hafsteinsson Gudjohnsen Stefan Arni Hafsteinsson Gudjohnsen Diahann A. M. Atacho Diahann A. M. Atacho Franck eGesbert Graca eRaposo Ilse eHurbain Ilse eHurbain Lionel eLarue Eirikur eSteingrimsson Petur Henry Petersen
spellingShingle	Stefan Arni Hafsteinsson Gudjohnsen Stefan Arni Hafsteinsson Gudjohnsen Diahann A. M. Atacho Diahann A. M. Atacho Franck eGesbert Graca eRaposo Ilse eHurbain Ilse eHurbain Lionel eLarue Eirikur eSteingrimsson Petur Henry Petersen Meningeal melanocytes in the mouse: Distribution and dependence on Mitf Frontiers in Neuroanatomy Melanocytes Meninges Mouse MITF meningeal melanoma.
author_facet	Stefan Arni Hafsteinsson Gudjohnsen Stefan Arni Hafsteinsson Gudjohnsen Diahann A. M. Atacho Diahann A. M. Atacho Franck eGesbert Graca eRaposo Ilse eHurbain Ilse eHurbain Lionel eLarue Eirikur eSteingrimsson Petur Henry Petersen
author_sort	Stefan Arni Hafsteinsson Gudjohnsen
title	Meningeal melanocytes in the mouse: Distribution and dependence on Mitf
title_short	Meningeal melanocytes in the mouse: Distribution and dependence on Mitf
title_full	Meningeal melanocytes in the mouse: Distribution and dependence on Mitf
title_fullStr	Meningeal melanocytes in the mouse: Distribution and dependence on Mitf
title_full_unstemmed	Meningeal melanocytes in the mouse: Distribution and dependence on Mitf
title_sort	meningeal melanocytes in the mouse: distribution and dependence on mitf
publisher	Frontiers Media S.A.
series	Frontiers in Neuroanatomy
issn	1662-5129
publishDate	2015-11-01
description	Melanocytes are pigment producing cells derived from the neural crest. They are primarily found in the skin and hair follicles, but can also be found in other tissues including the eye, ear and heart. Here we describe the distribution of pigmented cells in C57BL/6J mouse meninges, the membranes that envelope the brain. These cells contain melanosomes of all four stages of development and they depend on MITF, the master regulator of melanocyte development, suggesting that they are bona-fide melanocytes. The location of these pigmented cells is consistent with the location of meningeal melanomas in humans and animal models.
topic	Melanocytes Meninges Mouse MITF meningeal melanoma.
url	http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00149/full
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Meningeal melanocytes in the mouse: Distribution and dependence on Mitf

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