THE FREQUENCY AND ASSOCIATION OF RISK FACTORS IN DEVELOPMENT OF CORONARY HEART DISEASE IN DIABETES MELLITUS

• Main Authors: Dušan Sokolović, Slobodan Antić, Todorka Savić, Goran Damnjanović, Stojan Radić, Boris Đinđić
• Format: Article
• Language: English
• Published: University in Nis, Faculty of Medicine 2003-01-01
• Series: Acta Medica Medianae
• Subjects: diabetes; risc factors; coronary heart disease
• Online Access: http://publisher.medfak.ni.ac.rs/2003-html/1-broj/UCESTALOST%20I%20UDRUZENOST....pdf

The coronary heart disease (CHD) is a leading cause of lethality in both sexes. The risk for development of CHD is 2-4 times higher in non insulin dependent diabetes mellitus (NIDDM) than in nondiabetics, and annual rate of fatal and non-fatal cardiovascular diseases in NIDDM is 2-5%. The etiology of CHD is still unknown until the risk factors connected to the development of CHD are well known.The purpose of this research was to establish the frequency and importance of the risk factors in development of CHD in NIDDM.The research included 60 patients with NIDDM who were by presence of CHD classified into two groups. We determined body mass index and waist hip ratio, total and HDL cholesterol, triglicerides, LDL cholesterols, uric acid and fibrinogen.Values of BMI were statistically higher in patients with CHD than in diabetics without CHD 29.67+3.31 vs. 27.87±3.17 kg/m2 (p<0.05). Raised risk levels of cholesterol had90% with CHD and 76% without CHD (Hi2=6.12, p<0.05). Larger percentage of patients in group with CHD had raised lipid risk levels of triglicerides 70% than in patients without CHD 56.5% (Hi2=4.36, p<0.05). The obesity was relatively rare in patients without CHD than in diabetics with CHD (13.6% vs. 76%, p<0.01).The frequency of risk factors was very high in NIDDM patients, which clearly points at their cumulative effect in development of CHD in diabetics.