Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery From 5-Fluorouracil–Induced Oral Mucositis
Oral mucositis induced by chemotherapy or radiotherapy has an impact upon quality-of-life, is dose-limiting for chemotherapy, and causes considerable morbidity. We evaluated the effect of royal jelly (RJ) on 5-fluorouracil (5-FU)-induced oral mucositis in hamsters. Oral mucositis was induced in hams...
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doaj-9efb384f0f69419b8fcf8aee7bcf5c9d2020-11-24T23:52:10ZengElsevierJournal of Pharmacological Sciences1347-86132013-01-011212110118Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery From 5-Fluorouracil–Induced Oral MucositisShinichi Watanabe0Katsuya Suemaru1Kenshi Takechi2Hiroaki Kaji3Kimie Imai4Hiroaki Araki5Division of Pharmacy, Ehime University Hospital, 454 Shitsukawa, Toon, Ehime 791-0295, Japan; Corresponding author. kinnin@m.ehime-u.ac.jpSchool of Pharmacy, Shujitsu University, 1-6-1 Nishigawara, Okayama 703-8516, JapanDivision of Pharmacy, Ehime University Hospital, 454 Shitsukawa, Toon, Ehime 791-0295, JapanDivision of Biochemistry, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, 7-2-1 Kami-Ohno, Himeji, Hyogo 670-8524, JapanDivision of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, JapanDivision of Pharmacy, Ehime University Hospital, 454 Shitsukawa, Toon, Ehime 791-0295, JapanOral mucositis induced by chemotherapy or radiotherapy has an impact upon quality-of-life, is dose-limiting for chemotherapy, and causes considerable morbidity. We evaluated the effect of royal jelly (RJ) on 5-fluorouracil (5-FU)-induced oral mucositis in hamsters. Oral mucositis was induced in hamsters through a combination of 5-FU treatment and mild abrasion of the cheek pouch. RJ was contained in chitosan–sodium alginate film (RJ film). Films were attached to the oral mucosa and the healing process examined by measuring the area of mucositis, myeloperoxidase (MPO) activity, microscopic aspects, and RT-PCR for detection of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β). Furthermore, we evaluated the radical-scavenging activity of RJ and generation of keratinocyte growth factor from human periodontal ligament fibroblasts. RJ films (10%, 30%) significantly improved recovery from 5-FU–induced damage, reduced MPO activity and the production of pro-inflammatory cytokines. Additionally, RJ showed radical-scavenging activity. These data suggest that topical application of films that contain RJ had a healing effect on the severe oral mucositis induced by 5-FU and that the effect was caused by the anti-inflammatory or anti-oxidative activities of RJ. Keywords:: antioxidant, cancer, 5-fluorouracil, oral mucositis, royal jellyhttp://www.sciencedirect.com/science/article/pii/S134786131930386X |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shinichi Watanabe Katsuya Suemaru Kenshi Takechi Hiroaki Kaji Kimie Imai Hiroaki Araki |
spellingShingle |
Shinichi Watanabe Katsuya Suemaru Kenshi Takechi Hiroaki Kaji Kimie Imai Hiroaki Araki Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery From 5-Fluorouracil–Induced Oral Mucositis Journal of Pharmacological Sciences |
author_facet |
Shinichi Watanabe Katsuya Suemaru Kenshi Takechi Hiroaki Kaji Kimie Imai Hiroaki Araki |
author_sort |
Shinichi Watanabe |
title |
Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery From 5-Fluorouracil–Induced Oral Mucositis |
title_short |
Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery From 5-Fluorouracil–Induced Oral Mucositis |
title_full |
Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery From 5-Fluorouracil–Induced Oral Mucositis |
title_fullStr |
Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery From 5-Fluorouracil–Induced Oral Mucositis |
title_full_unstemmed |
Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery From 5-Fluorouracil–Induced Oral Mucositis |
title_sort |
oral mucosal adhesive films containing royal jelly accelerate recovery from 5-fluorouracil–induced oral mucositis |
publisher |
Elsevier |
series |
Journal of Pharmacological Sciences |
issn |
1347-8613 |
publishDate |
2013-01-01 |
description |
Oral mucositis induced by chemotherapy or radiotherapy has an impact upon quality-of-life, is dose-limiting for chemotherapy, and causes considerable morbidity. We evaluated the effect of royal jelly (RJ) on 5-fluorouracil (5-FU)-induced oral mucositis in hamsters. Oral mucositis was induced in hamsters through a combination of 5-FU treatment and mild abrasion of the cheek pouch. RJ was contained in chitosan–sodium alginate film (RJ film). Films were attached to the oral mucosa and the healing process examined by measuring the area of mucositis, myeloperoxidase (MPO) activity, microscopic aspects, and RT-PCR for detection of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β). Furthermore, we evaluated the radical-scavenging activity of RJ and generation of keratinocyte growth factor from human periodontal ligament fibroblasts. RJ films (10%, 30%) significantly improved recovery from 5-FU–induced damage, reduced MPO activity and the production of pro-inflammatory cytokines. Additionally, RJ showed radical-scavenging activity. These data suggest that topical application of films that contain RJ had a healing effect on the severe oral mucositis induced by 5-FU and that the effect was caused by the anti-inflammatory or anti-oxidative activities of RJ. Keywords:: antioxidant, cancer, 5-fluorouracil, oral mucositis, royal jelly |
url |
http://www.sciencedirect.com/science/article/pii/S134786131930386X |
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