Diffusion weighted imaging in early prediction of neoadjuvant chemotherapy response in breast cancer
Background: Neoadjuvant chemotherapy (NAC) has clinically important outcome. Early evaluation of the treatment response is important to avoid unnecessary therapy in non-responders. MRI is the most sensitive imaging for monitoring NAC response. Aim of this study: Is to test the ability of DWI to dete...
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doaj-9efd9d64f5b6459387ee4c539cb6c7032020-11-25T02:02:26ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine0378-603X2017-06-0148252953510.1016/j.ejrnm.2017.03.021Diffusion weighted imaging in early prediction of neoadjuvant chemotherapy response in breast cancerEman Abd Elrahim Mohamed El bakoury0Rawia Fawzy Khalil1Alaa Eldin Mohamed Abdelhamid2Azza Mohamed Amin Darwish3Hebatallah Hassan Mamdouh Hassan4Radiodiagnosis Department, Medical Research Institute, University of Alexandria, EgyptRadiodiagnosis Department, Medical Research Institute, University of Alexandria, EgyptDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, Alexandria University Hospital, EgyptDepartment of Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University Hospital, EgyptDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, Alexandria University Hospital, EgyptBackground: Neoadjuvant chemotherapy (NAC) has clinically important outcome. Early evaluation of the treatment response is important to avoid unnecessary therapy in non-responders. MRI is the most sensitive imaging for monitoring NAC response. Aim of this study: Is to test the ability of DWI to detect early response to NAC. Results: The study was performed on 20 patients, proved pathologically to have invasive breast cancer. All patients underwent breast MRI before initiation of NAC, after one cycle and after completion of the NAC protocol. Regarding the mass size, results showed no significant change in maximum mass diameters occur after the 1st NAC cycle. Absolute value of the ADC show increase all along the treatment course which has no significant correlation with the pathological response. The relative increase ADC more than 20% calculated from subtraction of the pre-treatment ADCmean value from that after the first NAC, subdividing the result on the pre-treatment ADCmean value and multiply it by 100 reflected significantly on the pathological response (p value of 0.011). Conclusion: ADC value can predict responder from non-responder as early as after the first cycle of chemotherapy.http://www.sciencedirect.com/science/article/pii/S0378603X17300669Breast cancerNeoadjuvantMRI breast diffusion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eman Abd Elrahim Mohamed El bakoury Rawia Fawzy Khalil Alaa Eldin Mohamed Abdelhamid Azza Mohamed Amin Darwish Hebatallah Hassan Mamdouh Hassan |
spellingShingle |
Eman Abd Elrahim Mohamed El bakoury Rawia Fawzy Khalil Alaa Eldin Mohamed Abdelhamid Azza Mohamed Amin Darwish Hebatallah Hassan Mamdouh Hassan Diffusion weighted imaging in early prediction of neoadjuvant chemotherapy response in breast cancer The Egyptian Journal of Radiology and Nuclear Medicine Breast cancer Neoadjuvant MRI breast diffusion |
author_facet |
Eman Abd Elrahim Mohamed El bakoury Rawia Fawzy Khalil Alaa Eldin Mohamed Abdelhamid Azza Mohamed Amin Darwish Hebatallah Hassan Mamdouh Hassan |
author_sort |
Eman Abd Elrahim Mohamed El bakoury |
title |
Diffusion weighted imaging in early prediction of neoadjuvant chemotherapy response in breast cancer |
title_short |
Diffusion weighted imaging in early prediction of neoadjuvant chemotherapy response in breast cancer |
title_full |
Diffusion weighted imaging in early prediction of neoadjuvant chemotherapy response in breast cancer |
title_fullStr |
Diffusion weighted imaging in early prediction of neoadjuvant chemotherapy response in breast cancer |
title_full_unstemmed |
Diffusion weighted imaging in early prediction of neoadjuvant chemotherapy response in breast cancer |
title_sort |
diffusion weighted imaging in early prediction of neoadjuvant chemotherapy response in breast cancer |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Radiology and Nuclear Medicine |
issn |
0378-603X |
publishDate |
2017-06-01 |
description |
Background: Neoadjuvant chemotherapy (NAC) has clinically important outcome. Early evaluation of the treatment response is important to avoid unnecessary therapy in non-responders. MRI is the most sensitive imaging for monitoring NAC response.
Aim of this study: Is to test the ability of DWI to detect early response to NAC.
Results: The study was performed on 20 patients, proved pathologically to have invasive breast cancer. All patients underwent breast MRI before initiation of NAC, after one cycle and after completion of the NAC protocol. Regarding the mass size, results showed no significant change in maximum mass diameters occur after the 1st NAC cycle. Absolute value of the ADC show increase all along the treatment course which has no significant correlation with the pathological response. The relative increase ADC more than 20% calculated from subtraction of the pre-treatment ADCmean value from that after the first NAC, subdividing the result on the pre-treatment ADCmean value and multiply it by 100 reflected significantly on the pathological response (p value of 0.011).
Conclusion: ADC value can predict responder from non-responder as early as after the first cycle of chemotherapy. |
topic |
Breast cancer Neoadjuvant MRI breast diffusion |
url |
http://www.sciencedirect.com/science/article/pii/S0378603X17300669 |
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