Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer
Epithelial ovarian cancer stem cells (EOC stem cells) have been associated with recurrence and chemoresistance. CD44 and CK18 are highly expressed in cancer stem cells and function as tools for their identification and characterization. We investigated the association between the number of CD44+ EOC...
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doaj-9eff225e473a41519b90fe0f07133c0d2020-11-24T20:55:20ZengHindawi LimitedJournal of Oncology1687-84501687-84692011-01-01201110.1155/2011/620523620523Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian CancerKarina Dahl Steffensen0Ayesha B. Alvero1Yang Yang2Marianne Waldstrøm3Pei Hui4Jennie C. Holmberg5Dan-Arin Silasi6Anders Jakobsen7Thomas Rutherford8Gil Mor9Department of Oncology, Vejle Hospital, Kabbeltoft 25, 7100 Vejle, DenmarkDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USADepartment of Pathology, Vejle Hospital, 7100 Vejle, DenmarkDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06510, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USADepartment of Oncology, Vejle Hospital, Kabbeltoft 25, 7100 Vejle, DenmarkDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USAEpithelial ovarian cancer stem cells (EOC stem cells) have been associated with recurrence and chemoresistance. CD44 and CK18 are highly expressed in cancer stem cells and function as tools for their identification and characterization. We investigated the association between the number of CD44+ EOC stem cells in ovarian cancer tumors and progression-free survival. EOC stem cells exist as clusters located close to the stroma forming the cancer stem cell “niche”. 17.1% of the samples reveled high number of CD44+ EOC stem cells (>20% positive cells). In addition, the number of CD44+ EOC stem cells was significantly higher in patients with early-stage ovarian cancer (FIGO I/II), and it was associated with shorter progression-free survival (P=0.026). This study suggests that quantification of the number of EOC stem cells in the tumor can be used as a predictor of disease and could be applied for treatment selection in early-stage ovarian cancer.http://dx.doi.org/10.1155/2011/620523 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karina Dahl Steffensen Ayesha B. Alvero Yang Yang Marianne Waldstrøm Pei Hui Jennie C. Holmberg Dan-Arin Silasi Anders Jakobsen Thomas Rutherford Gil Mor |
spellingShingle |
Karina Dahl Steffensen Ayesha B. Alvero Yang Yang Marianne Waldstrøm Pei Hui Jennie C. Holmberg Dan-Arin Silasi Anders Jakobsen Thomas Rutherford Gil Mor Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer Journal of Oncology |
author_facet |
Karina Dahl Steffensen Ayesha B. Alvero Yang Yang Marianne Waldstrøm Pei Hui Jennie C. Holmberg Dan-Arin Silasi Anders Jakobsen Thomas Rutherford Gil Mor |
author_sort |
Karina Dahl Steffensen |
title |
Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer |
title_short |
Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer |
title_full |
Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer |
title_fullStr |
Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer |
title_full_unstemmed |
Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer |
title_sort |
prevalence of epithelial ovarian cancer stem cells correlates with recurrence in early-stage ovarian cancer |
publisher |
Hindawi Limited |
series |
Journal of Oncology |
issn |
1687-8450 1687-8469 |
publishDate |
2011-01-01 |
description |
Epithelial ovarian cancer stem cells (EOC stem cells) have been associated with recurrence and chemoresistance. CD44 and CK18 are highly expressed in cancer stem cells and function as tools for their identification and characterization. We investigated the association between the number of CD44+ EOC stem cells in ovarian cancer tumors and progression-free survival. EOC stem cells exist as clusters located close to the stroma forming the cancer stem cell “niche”. 17.1% of the samples reveled high number of CD44+ EOC stem cells (>20% positive cells). In addition, the number of CD44+ EOC stem cells was significantly higher in patients with early-stage ovarian cancer (FIGO I/II), and it was associated with shorter progression-free survival (P=0.026). This study suggests that quantification of the number of EOC stem cells in the tumor can be used as a predictor of disease and could be applied for treatment selection in early-stage ovarian cancer. |
url |
http://dx.doi.org/10.1155/2011/620523 |
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