Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer

Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer

Epithelial ovarian cancer stem cells (EOC stem cells) have been associated with recurrence and chemoresistance. CD44 and CK18 are highly expressed in cancer stem cells and function as tools for their identification and characterization. We investigated the association between the number of CD44+ EOC...

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Main Authors: Karina Dahl Steffensen, Ayesha B. Alvero, Yang Yang, Marianne Waldstrøm, Pei Hui, Jennie C. Holmberg, Dan-Arin Silasi, Anders Jakobsen, Thomas Rutherford, Gil Mor
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Oncology
Online Access:http://dx.doi.org/10.1155/2011/620523
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spelling doaj-9eff225e473a41519b90fe0f07133c0d2020-11-24T20:55:20ZengHindawi LimitedJournal of Oncology1687-84501687-84692011-01-01201110.1155/2011/620523620523Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian CancerKarina Dahl Steffensen0Ayesha B. Alvero1Yang Yang2Marianne Waldstrøm3Pei Hui4Jennie C. Holmberg5Dan-Arin Silasi6Anders Jakobsen7Thomas Rutherford8Gil Mor9Department of Oncology, Vejle Hospital, Kabbeltoft 25, 7100 Vejle, DenmarkDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USADepartment of Pathology, Vejle Hospital, 7100 Vejle, DenmarkDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06510, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USADepartment of Oncology, Vejle Hospital, Kabbeltoft 25, 7100 Vejle, DenmarkDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USAEpithelial ovarian cancer stem cells (EOC stem cells) have been associated with recurrence and chemoresistance. CD44 and CK18 are highly expressed in cancer stem cells and function as tools for their identification and characterization. We investigated the association between the number of CD44+ EOC stem cells in ovarian cancer tumors and progression-free survival. EOC stem cells exist as clusters located close to the stroma forming the cancer stem cell “niche”. 17.1% of the samples reveled high number of CD44+ EOC stem cells (>20% positive cells). In addition, the number of CD44+ EOC stem cells was significantly higher in patients with early-stage ovarian cancer (FIGO I/II), and it was associated with shorter progression-free survival (P=0.026). This study suggests that quantification of the number of EOC stem cells in the tumor can be used as a predictor of disease and could be applied for treatment selection in early-stage ovarian cancer.http://dx.doi.org/10.1155/2011/620523
collection DOAJ
language English
format Article
sources DOAJ
author Karina Dahl Steffensen
Ayesha B. Alvero
Yang Yang
Marianne Waldstrøm
Pei Hui
Jennie C. Holmberg
Dan-Arin Silasi
Anders Jakobsen
Thomas Rutherford
Gil Mor
spellingShingle Karina Dahl Steffensen
Ayesha B. Alvero
Yang Yang
Marianne Waldstrøm
Pei Hui
Jennie C. Holmberg
Dan-Arin Silasi
Anders Jakobsen
Thomas Rutherford
Gil Mor
Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer
Journal of Oncology
author_facet Karina Dahl Steffensen
Ayesha B. Alvero
Yang Yang
Marianne Waldstrøm
Pei Hui
Jennie C. Holmberg
Dan-Arin Silasi
Anders Jakobsen
Thomas Rutherford
Gil Mor
author_sort Karina Dahl Steffensen
title Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer
title_short Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer
title_full Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer
title_fullStr Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer
title_full_unstemmed Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer
title_sort prevalence of epithelial ovarian cancer stem cells correlates with recurrence in early-stage ovarian cancer
publisher Hindawi Limited
series Journal of Oncology
issn 1687-8450
1687-8469
publishDate 2011-01-01
description Epithelial ovarian cancer stem cells (EOC stem cells) have been associated with recurrence and chemoresistance. CD44 and CK18 are highly expressed in cancer stem cells and function as tools for their identification and characterization. We investigated the association between the number of CD44+ EOC stem cells in ovarian cancer tumors and progression-free survival. EOC stem cells exist as clusters located close to the stroma forming the cancer stem cell “niche”. 17.1% of the samples reveled high number of CD44+ EOC stem cells (>20% positive cells). In addition, the number of CD44+ EOC stem cells was significantly higher in patients with early-stage ovarian cancer (FIGO I/II), and it was associated with shorter progression-free survival (P=0.026). This study suggests that quantification of the number of EOC stem cells in the tumor can be used as a predictor of disease and could be applied for treatment selection in early-stage ovarian cancer.
url http://dx.doi.org/10.1155/2011/620523
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