Vaccination with a Leishmania infantum HSP70-II null mutant confers long-term protective immunity against Leishmania major infection in two mice models.

Vaccination with a Leishmania infantum HSP70-II null mutant confers long-term protective immunity against Leishmania major infection in two mice models.

The immunization with genetically attenuated Leishmania cell lines has been associated to the induction of memory and effector T cell responses against Leishmania able to control subsequent challenges. A Leishmania infantum null mutant for the HSP70-II genes has been described, possessing a non-viru...

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Bibliographic Details
Main Authors: José Carlos Solana, Laura Ramírez, Laura Corvo, Camila Indiani de Oliveira, Manoel Barral-Netto, José María Requena, Salvador Iborra, Manuel Soto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-05-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5466331?pdf=render

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