Marked Differences in C9orf72 Methylation Status and Isoform Expression between C9/ALS Human Embryonic and Induced Pluripotent Stem Cells

Marked Differences in C9orf72 Methylation Status and Isoform Expression between C9/ALS Human Embryonic and Induced Pluripotent Stem Cells

We established two human embryonic stem cell (hESC) lines with a GGGGCC expansion in the C9orf72 gene (C9), and compared them with haploidentical and unrelated C9 induced pluripotent stem cells (iPSCs). We found a marked difference in C9 methylation between the cells. hESCs and parental fibroblasts...

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Bibliographic Details
Main Authors: Yaara Cohen-Hadad, Gheona Altarescu, Talia Eldar-Geva, Ephrat Levi-Lahad, Ming Zhang, Ekaterina Rogaeva, Marc Gotkine, Osnat Bartok, Reut Ashwal-Fluss, Sebastian Kadener, Silvina Epsztejn-Litman, Rachel Eiges
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Stem Cell Reports
Subjects:
C9/ALS
unstable repeat expansions
DNA methylation
CpG islands
pluripotent stem cells
disease modelling
neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111630217X

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http://www.sciencedirect.com/science/article/pii/S221367111630217X

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