The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis

The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis

Extracellular vesicles (EVs) play a key role in the communication between cancer cells and stromal components of the tumor microenvironment (TME). In this context, cancer cell-derived EVs can regulate the activation of a CAF phenotype in TME cells, which can be mediated by several EV cargos (e.g., m...

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Main Authors: Issraa Shoucair, Fernanda Weber Mello, James Jabalee, Saeideh Maleki, Cathie Garnis
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
extracellular vesicles
tumor microenvironment
cancer-associated fibroblasts
neoplasms
Online Access:https://www.mdpi.com/1422-0067/21/18/6837
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spelling doaj-9f14e19280234ce49af0b5025cca65aa2020-11-25T04:02:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-01216837683710.3390/ijms21186837The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in TumorigenesisIssraa Shoucair0Fernanda Weber Mello1James Jabalee2Saeideh Maleki3Cathie Garnis4Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, CanadaDepartment of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, CanadaDepartment of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, CanadaDepartment of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, CanadaDepartment of Surgery, University of British Columbia, Vancouver, BC V5Z 1M9, CanadaExtracellular vesicles (EVs) play a key role in the communication between cancer cells and stromal components of the tumor microenvironment (TME). In this context, cancer cell-derived EVs can regulate the activation of a CAF phenotype in TME cells, which can be mediated by several EV cargos (e.g., miRNA, proteins, mRNA and lncRNAs). On the other hand, CAF-derived EVs can mediate several processes during tumorigenesis, including tumor growth, invasion, metastasis, and therapy resistance. This review aimed to discuss the molecular aspects of EV-based cross-talk between CAFs and cancer cells during tumorigenesis, in addition to assessing the roles of EV cargo in therapy resistance and pre-metastatic niche formation.https://www.mdpi.com/1422-0067/21/18/6837extracellular vesiclestumor microenvironmentcancer-associated fibroblastsneoplasms
collection DOAJ
language English
format Article
sources DOAJ
author Issraa Shoucair
Fernanda Weber Mello
James Jabalee
Saeideh Maleki
Cathie Garnis
spellingShingle Issraa Shoucair
Fernanda Weber Mello
James Jabalee
Saeideh Maleki
Cathie Garnis
The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
International Journal of Molecular Sciences
extracellular vesicles
tumor microenvironment
cancer-associated fibroblasts
neoplasms
author_facet Issraa Shoucair
Fernanda Weber Mello
James Jabalee
Saeideh Maleki
Cathie Garnis
author_sort Issraa Shoucair
title The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
title_short The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
title_full The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
title_fullStr The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
title_full_unstemmed The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
title_sort role of cancer-associated fibroblasts and extracellular vesicles in tumorigenesis
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2020-09-01
description Extracellular vesicles (EVs) play a key role in the communication between cancer cells and stromal components of the tumor microenvironment (TME). In this context, cancer cell-derived EVs can regulate the activation of a CAF phenotype in TME cells, which can be mediated by several EV cargos (e.g., miRNA, proteins, mRNA and lncRNAs). On the other hand, CAF-derived EVs can mediate several processes during tumorigenesis, including tumor growth, invasion, metastasis, and therapy resistance. This review aimed to discuss the molecular aspects of EV-based cross-talk between CAFs and cancer cells during tumorigenesis, in addition to assessing the roles of EV cargo in therapy resistance and pre-metastatic niche formation.
topic extracellular vesicles
tumor microenvironment
cancer-associated fibroblasts
neoplasms
url https://www.mdpi.com/1422-0067/21/18/6837
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