HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy

HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy

Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of H...

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Main Authors: Lucie Janeckova, Michal Kolar, Jiri Svec, Lucie Lanikova, Vendula Pospichalova, Nikol Baloghova, Martina Vojtechova, Eva Sloncova, Hynek Strnad, Vladimir Korinek
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523315300644
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spelling doaj-9f1b1d985a2d49578ef07e9ef602a8192020-11-24T22:43:43ZengElsevierTranslational Oncology1936-52331944-71242016-04-01929910710.1016/j.tranon.2016.01.005HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to ChemotherapyLucie Janeckova0Michal Kolar1Jiri Svec2Lucie Lanikova3Vendula Pospichalova4Nikol Baloghova5Martina Vojtechova6Eva Sloncova7Hynek Strnad8Vladimir Korinek9Department of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech RepublicDepartment of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech RepublicDepartment of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech RepublicDepartment of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech RepublicDepartment of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech RepublicDepartment of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech RepublicDepartment of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech RepublicDepartment of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech RepublicDepartment of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech RepublicDepartment of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech RepublicNeoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specific region in the HIC1 locus. However, in carcinomas, the HIC1 expression was variable and, in some specimens, comparable to healthy tissue. Importantly, high HIC1 production distinguished a specific type of chemotherapy-responsive tumors.http://www.sciencedirect.com/science/article/pii/S1936523315300644
collection DOAJ
language English
format Article
sources DOAJ
author Lucie Janeckova
Michal Kolar
Jiri Svec
Lucie Lanikova
Vendula Pospichalova
Nikol Baloghova
Martina Vojtechova
Eva Sloncova
Hynek Strnad
Vladimir Korinek
spellingShingle Lucie Janeckova
Michal Kolar
Jiri Svec
Lucie Lanikova
Vendula Pospichalova
Nikol Baloghova
Martina Vojtechova
Eva Sloncova
Hynek Strnad
Vladimir Korinek
HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy
Translational Oncology
author_facet Lucie Janeckova
Michal Kolar
Jiri Svec
Lucie Lanikova
Vendula Pospichalova
Nikol Baloghova
Martina Vojtechova
Eva Sloncova
Hynek Strnad
Vladimir Korinek
author_sort Lucie Janeckova
title HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy
title_short HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy
title_full HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy
title_fullStr HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy
title_full_unstemmed HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy
title_sort hic1 expression distinguishes intestinal carcinomas sensitive to chemotherapy
publisher Elsevier
series Translational Oncology
issn 1936-5233
1944-7124
publishDate 2016-04-01
description Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specific region in the HIC1 locus. However, in carcinomas, the HIC1 expression was variable and, in some specimens, comparable to healthy tissue. Importantly, high HIC1 production distinguished a specific type of chemotherapy-responsive tumors.
url http://www.sciencedirect.com/science/article/pii/S1936523315300644
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AT jirisvec hic1expressiondistinguishesintestinalcarcinomassensitivetochemotherapy
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