Crosstalk between the microbiota-gut-brain axis and depression
Nutritional and microbiological psychiatry, especially the contribution of the gut microbiota to depression, has become a promising research field over the past several decades. An imbalance in the “microbiota-gut-brain axis”, which reflects the constant bidirectional communication between the centr...
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doaj-9f1cbd7db480470ca2024ae415eb39562020-11-25T02:57:45ZengElsevierHeliyon2405-84402020-06-0166e04097Crosstalk between the microbiota-gut-brain axis and depressionYu Du0Xin-Ran Gao1Lei Peng2Jin-Fang Ge3School of Pharmacy, Anhui Medical University, Hefei, ChinaSchool of Pharmacy, Anhui Medical University, Hefei, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Medical University, Hefei, ChinaSchool of Pharmacy, Anhui Medical University, Hefei, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Medical University, Hefei, ChinaSchool of Pharmacy, Anhui Medical University, Hefei, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Medical University, Hefei, China; Corresponding author.Nutritional and microbiological psychiatry, especially the contribution of the gut microbiota to depression, has become a promising research field over the past several decades. An imbalance in the “microbiota-gut-brain axis”, which reflects the constant bidirectional communication between the central nervous system and the gastrointestinal tract, has been used as a hypothesis to interpret the pathogenesis of depression. Alterations in gut microbiota composition could increase the permeability of the gut barrier, activate systemic inflammation and immune responses, regulate the release and efficacy of monoamine neurotransmitters, alter the activity and function of the hypothalamic-pituitary-adrenal (HPA) axis, and modify the abundance of brain-derived neurotrophic factor (BDNF), eventually leading to depression. In this article, we review changes in gut microbiota in depressive states, the association between these changes and depression-like behavior, the potential mechanism linking gut microbiota disruptions and depression, and preliminary attempts at using gut microbiota intervention for the treatment of depression. In summary, although the link between gut microbiota and depression and the potential mechanism have been discussed, a more detailed mechanistic understanding is needed to fully realize the importance of the microbiota-gut-brain axis in depression. Future efforts should aim to determine the potential causative mechanisms, which will require further animal and clinical research as well as the development of analytical approaches.http://www.sciencedirect.com/science/article/pii/S2405844020309415NeuroscienceImmunologyNeurologyPsychiatryMicrobiota-gut-brain axisDepression |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu Du Xin-Ran Gao Lei Peng Jin-Fang Ge |
spellingShingle |
Yu Du Xin-Ran Gao Lei Peng Jin-Fang Ge Crosstalk between the microbiota-gut-brain axis and depression Heliyon Neuroscience Immunology Neurology Psychiatry Microbiota-gut-brain axis Depression |
author_facet |
Yu Du Xin-Ran Gao Lei Peng Jin-Fang Ge |
author_sort |
Yu Du |
title |
Crosstalk between the microbiota-gut-brain axis and depression |
title_short |
Crosstalk between the microbiota-gut-brain axis and depression |
title_full |
Crosstalk between the microbiota-gut-brain axis and depression |
title_fullStr |
Crosstalk between the microbiota-gut-brain axis and depression |
title_full_unstemmed |
Crosstalk between the microbiota-gut-brain axis and depression |
title_sort |
crosstalk between the microbiota-gut-brain axis and depression |
publisher |
Elsevier |
series |
Heliyon |
issn |
2405-8440 |
publishDate |
2020-06-01 |
description |
Nutritional and microbiological psychiatry, especially the contribution of the gut microbiota to depression, has become a promising research field over the past several decades. An imbalance in the “microbiota-gut-brain axis”, which reflects the constant bidirectional communication between the central nervous system and the gastrointestinal tract, has been used as a hypothesis to interpret the pathogenesis of depression. Alterations in gut microbiota composition could increase the permeability of the gut barrier, activate systemic inflammation and immune responses, regulate the release and efficacy of monoamine neurotransmitters, alter the activity and function of the hypothalamic-pituitary-adrenal (HPA) axis, and modify the abundance of brain-derived neurotrophic factor (BDNF), eventually leading to depression. In this article, we review changes in gut microbiota in depressive states, the association between these changes and depression-like behavior, the potential mechanism linking gut microbiota disruptions and depression, and preliminary attempts at using gut microbiota intervention for the treatment of depression. In summary, although the link between gut microbiota and depression and the potential mechanism have been discussed, a more detailed mechanistic understanding is needed to fully realize the importance of the microbiota-gut-brain axis in depression. Future efforts should aim to determine the potential causative mechanisms, which will require further animal and clinical research as well as the development of analytical approaches. |
topic |
Neuroscience Immunology Neurology Psychiatry Microbiota-gut-brain axis Depression |
url |
http://www.sciencedirect.com/science/article/pii/S2405844020309415 |
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