Therapeutic role of long non-coding RNA TCONS_00019174 in depressive disorders is dependent on Wnt/$\beta$-catenin signaling pathway
Chronic stress is one of the major causes that lead to major depressive disorder, which is a prevalent mood disorder worldwide. Many patients with major depressive disorder do not benefit from available medication due to the complex etiology of the condition. Recently, long non-coding RNAs, molecula...
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doaj-9f2e07414e2349379701c25d093197912020-11-25T03:24:39ZengIMR (Innovative Medical Research) Press LimitedJournal of Integrative Neuroscience1757-448X2018-05-0117212513210.31083/JIN-170052Therapeutic role of long non-coding RNA TCONS_00019174 in depressive disorders is dependent on Wnt/$\beta$-catenin signaling pathwayXinqiang Ni, Yingzhao Liao, Limin Li, Xiaoli Zhang, Zhengzhi WuChronic stress is one of the major causes that lead to major depressive disorder, which is a prevalent mood disorder worldwide. Many patients with major depressive disorder do not benefit from available medication due to the complex etiology of the condition. Recently, long non-coding RNAs, molecular switches of downstream genes expression, have been reported to be involved in the pathogenesis of major depressive disorder. The long non-coding RNA TCONS_00019174 has been implicated in major depressive disorder risk and antidepressant effects, However, the effect of long non-coding RNA TCONS_00019174 on antidepressant responses has not been investigated. This study is designed to determine whether altered expression of long non-coding RNA TCONS_00019174 contributes to depression-like behaviors associated with chronic stress. We found that mice exposed to chronic ultra-mild stress displayed apparent depression-like behaviors and decreased expression of long non-coding RNA TCONS_00019174 in hippocampus. Both changed behaviors and long non-coding RNA TCONS_00019174 expression level were rescued by chronic treatment with imipramine. Viral-mediated long non-coding RNA TCONS_00019174 overexpression in hippocampal neurons improved the behaviors of mice exposed to chronic ultra-mild stress. Further, it was found long non-coding RNA TCONS_00019174 overexpression upregulated phosphorylated-GSK3$\beta$(p-GSK3$\beta$) protein and $\beta$-catenin in the hippocampus. These findings suggest that long non-coding RNA TCONS_00019174 exerts antidepressant-like effect in mice by activating a Wnt/$\beta$-catenin pathway, and that long non-coding RNA may serve as a potential therapeutic target for major depressive disorder in clinical application.https://jin.imrpress.com/fileup/1757-448X/PDF/1546080037424-1346975727.pdf|long non-coding rna|long non-coding rna tcons_00019174|depression|chronic stress mouse model|gsk3$\beta$|$\beta$-catenin pathway |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xinqiang Ni, Yingzhao Liao, Limin Li, Xiaoli Zhang, Zhengzhi Wu |
spellingShingle |
Xinqiang Ni, Yingzhao Liao, Limin Li, Xiaoli Zhang, Zhengzhi Wu Therapeutic role of long non-coding RNA TCONS_00019174 in depressive disorders is dependent on Wnt/$\beta$-catenin signaling pathway Journal of Integrative Neuroscience |long non-coding rna|long non-coding rna tcons_00019174|depression|chronic stress mouse model|gsk3$\beta$|$\beta$-catenin pathway |
author_facet |
Xinqiang Ni, Yingzhao Liao, Limin Li, Xiaoli Zhang, Zhengzhi Wu |
author_sort |
Xinqiang Ni, Yingzhao Liao, Limin Li, Xiaoli Zhang, Zhengzhi Wu |
title |
Therapeutic role of long non-coding RNA TCONS_00019174 in depressive disorders is dependent on Wnt/$\beta$-catenin signaling pathway |
title_short |
Therapeutic role of long non-coding RNA TCONS_00019174 in depressive disorders is dependent on Wnt/$\beta$-catenin signaling pathway |
title_full |
Therapeutic role of long non-coding RNA TCONS_00019174 in depressive disorders is dependent on Wnt/$\beta$-catenin signaling pathway |
title_fullStr |
Therapeutic role of long non-coding RNA TCONS_00019174 in depressive disorders is dependent on Wnt/$\beta$-catenin signaling pathway |
title_full_unstemmed |
Therapeutic role of long non-coding RNA TCONS_00019174 in depressive disorders is dependent on Wnt/$\beta$-catenin signaling pathway |
title_sort |
therapeutic role of long non-coding rna tcons_00019174 in depressive disorders is dependent on wnt/$\beta$-catenin signaling pathway |
publisher |
IMR (Innovative Medical Research) Press Limited |
series |
Journal of Integrative Neuroscience |
issn |
1757-448X |
publishDate |
2018-05-01 |
description |
Chronic stress is one of the major causes that lead to major depressive disorder, which is a prevalent mood disorder worldwide. Many patients with major depressive disorder do not benefit from available medication due to the complex etiology of the condition. Recently, long non-coding RNAs, molecular switches of downstream genes expression, have been reported to be involved in the pathogenesis of major depressive disorder. The long non-coding RNA TCONS_00019174 has been implicated in major depressive disorder risk and antidepressant effects, However, the effect of long non-coding RNA TCONS_00019174 on antidepressant responses has not been investigated. This study is designed to determine whether altered expression of long non-coding RNA TCONS_00019174 contributes to depression-like behaviors associated with chronic stress. We found that mice exposed to chronic ultra-mild stress displayed apparent depression-like behaviors and decreased expression of long non-coding RNA TCONS_00019174 in hippocampus. Both changed behaviors and long non-coding RNA TCONS_00019174 expression level were rescued by chronic treatment with imipramine. Viral-mediated long non-coding RNA TCONS_00019174 overexpression in hippocampal neurons improved the behaviors of mice exposed to chronic ultra-mild stress. Further, it was found long non-coding RNA TCONS_00019174 overexpression upregulated phosphorylated-GSK3$\beta$(p-GSK3$\beta$) protein and $\beta$-catenin in the hippocampus. These findings suggest that long non-coding RNA TCONS_00019174 exerts antidepressant-like effect in mice by activating a Wnt/$\beta$-catenin pathway, and that long non-coding RNA may serve as a potential therapeutic target for major depressive disorder in clinical application. |
topic |
|long non-coding rna|long non-coding rna tcons_00019174|depression|chronic stress mouse model|gsk3$\beta$|$\beta$-catenin pathway |
url |
https://jin.imrpress.com/fileup/1757-448X/PDF/1546080037424-1346975727.pdf |
work_keys_str_mv |
AT xinqiangniyingzhaoliaoliminlixiaolizhangzhengzhiwu therapeuticroleoflongnoncodingrnatcons00019174indepressivedisordersisdependentonwntbetacateninsignalingpathway |
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