Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19
It is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who requi...
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Format: | Article |
Language: | English |
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MDPI AG
2020-09-01
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Series: | Journal of Clinical Medicine |
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Online Access: | https://www.mdpi.com/2077-0383/9/10/3136 |
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doaj-9f308aa5ac5e4c1ba392f7f7f3800c72 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Enrique Rodilla Alberto Saura Iratxe Jiménez Andrea Mendizábal Araceli Pineda-Cantero Elizabeth Lorenzo-Hernández Maria del Pilar Fidalgo-Montero Joaquín Fernandez López-Cuervo Ricardo Gil-Sánchez Elisa Rabadán-Pejenaute Lucy Abella-Vázquez Vicente Giner-Galvañ Marta Nataya Solís-Marquínez Ramon Boixeda Andrés de la Peña-Fernández Francisco Javier Carrasco-Sánchez Julio González-Moraleja José David Torres-Peña María Esther Guisado-Espartero Joaquín Escobar-Sevilla Marcos Guzmán-García María Dolores Martín-Escalante Ángel Luis Martínez-González José Manuel Casas-Rojo Ricardo Gómez-Huelgas |
spellingShingle |
Enrique Rodilla Alberto Saura Iratxe Jiménez Andrea Mendizábal Araceli Pineda-Cantero Elizabeth Lorenzo-Hernández Maria del Pilar Fidalgo-Montero Joaquín Fernandez López-Cuervo Ricardo Gil-Sánchez Elisa Rabadán-Pejenaute Lucy Abella-Vázquez Vicente Giner-Galvañ Marta Nataya Solís-Marquínez Ramon Boixeda Andrés de la Peña-Fernández Francisco Javier Carrasco-Sánchez Julio González-Moraleja José David Torres-Peña María Esther Guisado-Espartero Joaquín Escobar-Sevilla Marcos Guzmán-García María Dolores Martín-Escalante Ángel Luis Martínez-González José Manuel Casas-Rojo Ricardo Gómez-Huelgas Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19 Journal of Clinical Medicine hypertension COVID-19 angiotensin-converting enzyme inhibitors (ACEIs) angiotensin II receptor blockers (ARBs) all-cause mortality |
author_facet |
Enrique Rodilla Alberto Saura Iratxe Jiménez Andrea Mendizábal Araceli Pineda-Cantero Elizabeth Lorenzo-Hernández Maria del Pilar Fidalgo-Montero Joaquín Fernandez López-Cuervo Ricardo Gil-Sánchez Elisa Rabadán-Pejenaute Lucy Abella-Vázquez Vicente Giner-Galvañ Marta Nataya Solís-Marquínez Ramon Boixeda Andrés de la Peña-Fernández Francisco Javier Carrasco-Sánchez Julio González-Moraleja José David Torres-Peña María Esther Guisado-Espartero Joaquín Escobar-Sevilla Marcos Guzmán-García María Dolores Martín-Escalante Ángel Luis Martínez-González José Manuel Casas-Rojo Ricardo Gómez-Huelgas |
author_sort |
Enrique Rodilla |
title |
Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19 |
title_short |
Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19 |
title_full |
Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19 |
title_fullStr |
Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19 |
title_full_unstemmed |
Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19 |
title_sort |
association of hypertension with all-cause mortality among hospitalized patients with covid-19 |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-09-01 |
description |
It is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who required hospital admission in 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics of survivors versus non-survivors. The mean age of the study population was 67.5 ± 16.1 years, 42.6% were women. Overall, 2630 (21.5%) subjects died. The most common comorbidity was hypertension (50.9%) followed by diabetes (19.1%), and atrial fibrillation (11.2%). Multivariate analysis showed that after adjusting for gender (males, OR: 1.5, <i>p</i> = 0.0001), age tertiles (second and third tertiles, OR: 2.0 and 4.7, <i>p</i> = 0.0001), and Charlson Comorbidity Index scores (second and third tertiles, OR: 4.7 and 8.1, <i>p</i> = 0.0001), hypertension was significantly predictive of all-cause mortality when this comorbidity was treated with angiotensin-converting enzyme inhibitors (ACEIs) (OR: 1.6, <i>p</i> = 0.002) or other than renin-angiotensin-aldosterone blockers (OR: 1.3, <i>p</i> = 0.001) or angiotensin II receptor blockers (ARBs) (OR: 1.2, <i>p</i> = 0.035). The preexisting condition of hypertension had an independent prognostic value for all-cause mortality in patients with COVID-19 who required hospitalization. ARBs showed a lower risk of lethality in hypertensive patients than other antihypertensive drugs. |
topic |
hypertension COVID-19 angiotensin-converting enzyme inhibitors (ACEIs) angiotensin II receptor blockers (ARBs) all-cause mortality |
url |
https://www.mdpi.com/2077-0383/9/10/3136 |
work_keys_str_mv |
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doaj-9f308aa5ac5e4c1ba392f7f7f3800c722020-11-25T03:39:54ZengMDPI AGJournal of Clinical Medicine2077-03832020-09-0193136313610.3390/jcm9103136Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19Enrique Rodilla0Alberto Saura1Iratxe Jiménez2Andrea Mendizábal3Araceli Pineda-Cantero4Elizabeth Lorenzo-Hernández5Maria del Pilar Fidalgo-Montero6Joaquín Fernandez López-Cuervo7Ricardo Gil-Sánchez8Elisa Rabadán-Pejenaute9Lucy Abella-Vázquez10Vicente Giner-Galvañ11Marta Nataya Solís-Marquínez12Ramon Boixeda13Andrés de la Peña-Fernández14Francisco Javier Carrasco-Sánchez15Julio González-Moraleja16José David Torres-Peña17María Esther Guisado-Espartero18Joaquín Escobar-Sevilla19Marcos Guzmán-García20María Dolores Martín-Escalante21Ángel Luis Martínez-González22José Manuel Casas-Rojo23Ricardo Gómez-Huelgas24Internal Medicine Department, University Hospital of Sagunto, Universidad Cardenal Herrera-CEU, CEU Universities, 46520 Sagunto, SpainInternal Medicine Department, University Hospital of Sagunto, Universidad Cardenal Herrera-CEU, CEU Universities, 46520 Sagunto, SpainInternal Medicine Department, University Hospital of Sagunto, Universidad Cardenal Herrera-CEU, CEU Universities, 46520 Sagunto, SpainInternal Medicine Department, University Hospital of Sagunto, Universidad Cardenal Herrera-CEU, CEU Universities, 46520 Sagunto, SpainInternal Medicine Department, Regional University Hospital of Málaga, 29010 Málaga, SpainInternal Medicine Department, Regional University Hospital of Málaga, 29010 Málaga, SpainInternal Medicine Department, Henares Hospital, 28822 Coslada (Madrid), SpainInternal Medicine Department, Torrevieja University Hospital, 03186 Torrevieja (Alicante), SpainInternal Medicine Department, La Fe University Hospital, 46026 Valencia, SpainInternal Medicine Department, San Pedro Hospital, 26006 Logroño (La Rioja), SpainInternal Medicine Department, Ntra Sra Candelaria University Hospital, 38010 Santa Cruz de Tenerife, SpainInternal Medicine Department, Hypertension and Cardiometabolic Risk Unit, San Juan de Alicante University Hospital, Miguel Hernández University, 03550 San Juan de Alicante (Alicante), SpainInternal Medicine Department, San Agustin University Hospital, 33410 Avilés (Asturias), SpainInternal Medicine Department, Mataró Hospital, 08304 Mataró, Barcelona, SpainInternal Medicine Department, Son Llàtzer University Hospital, 07198 Palma de Mallorca, SpainInternal Medicine Department, Juan Ramón Jiménez Hospital, 21005 Huelva, SpainInternal Medicine Department, Virgen de la Salud Hospital, 45004 Toledo, SpainInternal Medicine Department, Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 14004 Cordoba, SpainInternal Medicine Department, Infanta Margarita Hospital, 14940 Cabra (Córdoba), SpainInternal Medicine Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainInternal Medicine Department, San Juan de la Cruz Hospital, 23400 Úbeda (Jaén), SpainInternal Medicine Department, Costa del Sol Hospital, 29603 Marbella (Málaga), SpainInternal Medicine Department, León University Hospital Complex, 24008 León, SpainInternal Medicine Department, Infanta Cristina University Hospital, 28981 Parla (Madrid), SpainInternal Medicine Department, Regional University Hospital of Málaga, 29010 Málaga, SpainIt is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who required hospital admission in 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics of survivors versus non-survivors. The mean age of the study population was 67.5 ± 16.1 years, 42.6% were women. Overall, 2630 (21.5%) subjects died. The most common comorbidity was hypertension (50.9%) followed by diabetes (19.1%), and atrial fibrillation (11.2%). Multivariate analysis showed that after adjusting for gender (males, OR: 1.5, <i>p</i> = 0.0001), age tertiles (second and third tertiles, OR: 2.0 and 4.7, <i>p</i> = 0.0001), and Charlson Comorbidity Index scores (second and third tertiles, OR: 4.7 and 8.1, <i>p</i> = 0.0001), hypertension was significantly predictive of all-cause mortality when this comorbidity was treated with angiotensin-converting enzyme inhibitors (ACEIs) (OR: 1.6, <i>p</i> = 0.002) or other than renin-angiotensin-aldosterone blockers (OR: 1.3, <i>p</i> = 0.001) or angiotensin II receptor blockers (ARBs) (OR: 1.2, <i>p</i> = 0.035). The preexisting condition of hypertension had an independent prognostic value for all-cause mortality in patients with COVID-19 who required hospitalization. ARBs showed a lower risk of lethality in hypertensive patients than other antihypertensive drugs.https://www.mdpi.com/2077-0383/9/10/3136hypertensionCOVID-19angiotensin-converting enzyme inhibitors (ACEIs)angiotensin II receptor blockers (ARBs)all-cause mortality |