Long-term exposure to black carbon and mortality: A 28-year follow-up of the GAZEL cohort
Background: The current evidence on health effects of long-term exposure to outdoor airborne black carbon (BC) exposure remains scarce. Objectives: To examine the association between long-term exposure to BC and mortality in a large population-based French cohort, with 28 years of follow-up. Methods...
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doaj-9f3f2634076c468b8a7a6cf7e81d7ab42021-10-01T04:46:11ZengElsevierEnvironment International0160-41202021-12-01157106805Long-term exposure to black carbon and mortality: A 28-year follow-up of the GAZEL cohortJun Yang0Mohammad Javad Zare Sakhvidi1Kees de Hoogh2Danielle Vienneau3Jack Siemiatyck4Marie Zins5Marcel Goldberg6Jie Chen7Emeline Lequy8Bénédicte Jacquemin9Univ. Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) – UMR_S 1085, F-35000 Rennes, France; Institute for Environmental and Climate Research, Jinan University, Guangzhou 511443, ChinaUniv. Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) – UMR_S 1085, F-35000 Rennes, FranceSwiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, SwitzerlandSwiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, SwitzerlandCRCHUM (Centre de recherche du CHUM), Montréal, Québec, CanadaUniversité de Paris, Unité “Cohortes en Population” INSERM, Université Paris Saclay, UVSQ, UMS 011 Paris, FranceUniversité de Paris, Unité “Cohortes en Population” INSERM, Université Paris Saclay, UVSQ, UMS 011 Paris, FranceInstitute for Risk Assessment Sciences, Utrecht University, the NetherlandsCRCHUM (Centre de recherche du CHUM), Montréal, Québec, Canada; Université de Paris, Unité “Cohortes en Population” INSERM, Université Paris Saclay, UVSQ, UMS 011 Paris, FranceUniv. Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) – UMR_S 1085, F-35000 Rennes, France; Corresponding author.Background: The current evidence on health effects of long-term exposure to outdoor airborne black carbon (BC) exposure remains scarce. Objectives: To examine the association between long-term exposure to BC and mortality in a large population-based French cohort, with 28 years of follow-up. Methods: Data from the GAZEL cohort were collected between 1989 and 2017. Land use regression model with temporal extrapolation wa used to estimate yearly BC and PM2.5 exposure at the residential addresses from 1989 until censoring for 19,906 participants. Time-varying Cox models with attained age as time-scale was used to estimate the associations between BC and all-cause and cardiovascular mortality, after adjusting for individual and area-level covariates. To handle confounding by PM2.5, we used the residual of BC regressed on PM2.5 as an alternate exposure variable. For all-cause mortality, we also examined effect modification by sex, smoking status, BMI and fruit/vegetable intake. Results: The median of 20-year moving average of BC exposure was 2.02 10−5/m in study population. We found significant associations between BC exposure and all-cause mortality (n = 2357) using both 20-year moving average of BC and residual of BC, with corresponding hazard ratios (HR) of 1.14 (95 %CI: 1.07–1.22) and 1.17 (95 %CI: 1.10–1.24) for an inter-quartile range (IQR) increase (0.86 10−5/m for BC and 0.57 10−5/m for residual of BC). We found a similar association between BC and cardiovascular mortality (n = 277) with a HR of 1.15 (95 %CI: 0.95–1.38). The dose–response relationship between BC and all-cause mortality was monotonic but nonlinear with a steeper slope at high BC levels. In addition, the effect of BC was higher among never-smokers and among those having fruit/vegetables less than twice a week. Conclusions: There was a positive association between long-term exposure to BC and increased mortality risk, reinforcing the emerging evidence that BC is a harmful component of PM2.5.http://www.sciencedirect.com/science/article/pii/S016041202100430XAir pollutantBlack carbonMortalityLong-term exposureCohort study |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jun Yang Mohammad Javad Zare Sakhvidi Kees de Hoogh Danielle Vienneau Jack Siemiatyck Marie Zins Marcel Goldberg Jie Chen Emeline Lequy Bénédicte Jacquemin |
spellingShingle |
Jun Yang Mohammad Javad Zare Sakhvidi Kees de Hoogh Danielle Vienneau Jack Siemiatyck Marie Zins Marcel Goldberg Jie Chen Emeline Lequy Bénédicte Jacquemin Long-term exposure to black carbon and mortality: A 28-year follow-up of the GAZEL cohort Environment International Air pollutant Black carbon Mortality Long-term exposure Cohort study |
author_facet |
Jun Yang Mohammad Javad Zare Sakhvidi Kees de Hoogh Danielle Vienneau Jack Siemiatyck Marie Zins Marcel Goldberg Jie Chen Emeline Lequy Bénédicte Jacquemin |
author_sort |
Jun Yang |
title |
Long-term exposure to black carbon and mortality: A 28-year follow-up of the GAZEL cohort |
title_short |
Long-term exposure to black carbon and mortality: A 28-year follow-up of the GAZEL cohort |
title_full |
Long-term exposure to black carbon and mortality: A 28-year follow-up of the GAZEL cohort |
title_fullStr |
Long-term exposure to black carbon and mortality: A 28-year follow-up of the GAZEL cohort |
title_full_unstemmed |
Long-term exposure to black carbon and mortality: A 28-year follow-up of the GAZEL cohort |
title_sort |
long-term exposure to black carbon and mortality: a 28-year follow-up of the gazel cohort |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2021-12-01 |
description |
Background: The current evidence on health effects of long-term exposure to outdoor airborne black carbon (BC) exposure remains scarce. Objectives: To examine the association between long-term exposure to BC and mortality in a large population-based French cohort, with 28 years of follow-up. Methods: Data from the GAZEL cohort were collected between 1989 and 2017. Land use regression model with temporal extrapolation wa used to estimate yearly BC and PM2.5 exposure at the residential addresses from 1989 until censoring for 19,906 participants. Time-varying Cox models with attained age as time-scale was used to estimate the associations between BC and all-cause and cardiovascular mortality, after adjusting for individual and area-level covariates. To handle confounding by PM2.5, we used the residual of BC regressed on PM2.5 as an alternate exposure variable. For all-cause mortality, we also examined effect modification by sex, smoking status, BMI and fruit/vegetable intake. Results: The median of 20-year moving average of BC exposure was 2.02 10−5/m in study population. We found significant associations between BC exposure and all-cause mortality (n = 2357) using both 20-year moving average of BC and residual of BC, with corresponding hazard ratios (HR) of 1.14 (95 %CI: 1.07–1.22) and 1.17 (95 %CI: 1.10–1.24) for an inter-quartile range (IQR) increase (0.86 10−5/m for BC and 0.57 10−5/m for residual of BC). We found a similar association between BC and cardiovascular mortality (n = 277) with a HR of 1.15 (95 %CI: 0.95–1.38). The dose–response relationship between BC and all-cause mortality was monotonic but nonlinear with a steeper slope at high BC levels. In addition, the effect of BC was higher among never-smokers and among those having fruit/vegetables less than twice a week. Conclusions: There was a positive association between long-term exposure to BC and increased mortality risk, reinforcing the emerging evidence that BC is a harmful component of PM2.5. |
topic |
Air pollutant Black carbon Mortality Long-term exposure Cohort study |
url |
http://www.sciencedirect.com/science/article/pii/S016041202100430X |
work_keys_str_mv |
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