Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease
Chronic kidney disease and reduced glomerular filtration rate are risk factors for the development of chronic metabolic acidosis. The prevention or correction of chronic metabolic acidosis has been found to slow progression of chronic kidney disease. Dietary composition can strongly affect acid&...
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doaj-9f44da22e68441569ef05472846a9c312020-11-24T22:49:36ZengMDPI AGNutrients2072-66432018-04-0110451210.3390/nu10040512nu10040512Dietary Treatment of Metabolic Acidosis in Chronic Kidney DiseaseRoswitha Siener0University Stone Centre, Department of Urology, University of Bonn, Sigmund-Freud-Straße 25, D-53105 Bonn, GermanyChronic kidney disease and reduced glomerular filtration rate are risk factors for the development of chronic metabolic acidosis. The prevention or correction of chronic metabolic acidosis has been found to slow progression of chronic kidney disease. Dietary composition can strongly affect acid–base balance. Major determinants of net endogenous acid production are the generation of large amounts of hydrogen ions, mostly by animal-derived protein, which is counterbalanced by the metabolism of base-producing foods like fruits and vegetables. Alkali therapy of chronic metabolic acidosis can be achieved by providing an alkali-rich diet or oral administration of alkali salts. The primary goal of dietary treatment should be to increase the proportion of fruits and vegetables and to reduce the daily protein intake to 0.8–1.0 g per kg body weight. Diet modifications should begin early, i.e., even in patients with moderate kidney impairment, because usual dietary habits of many developed societies contribute an increased proportion of acid equivalents due to the high intake of protein from animal sources.http://www.mdpi.com/2072-6643/10/4/512metabolic acidosiskidney diseaseurolithiasisurinary stonesproteinfruitsvegetablesbicarbonatealkali citrate |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Roswitha Siener |
spellingShingle |
Roswitha Siener Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease Nutrients metabolic acidosis kidney disease urolithiasis urinary stones protein fruits vegetables bicarbonate alkali citrate |
author_facet |
Roswitha Siener |
author_sort |
Roswitha Siener |
title |
Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease |
title_short |
Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease |
title_full |
Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease |
title_fullStr |
Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease |
title_full_unstemmed |
Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease |
title_sort |
dietary treatment of metabolic acidosis in chronic kidney disease |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-04-01 |
description |
Chronic kidney disease and reduced glomerular filtration rate are risk factors for the development of chronic metabolic acidosis. The prevention or correction of chronic metabolic acidosis has been found to slow progression of chronic kidney disease. Dietary composition can strongly affect acid–base balance. Major determinants of net endogenous acid production are the generation of large amounts of hydrogen ions, mostly by animal-derived protein, which is counterbalanced by the metabolism of base-producing foods like fruits and vegetables. Alkali therapy of chronic metabolic acidosis can be achieved by providing an alkali-rich diet or oral administration of alkali salts. The primary goal of dietary treatment should be to increase the proportion of fruits and vegetables and to reduce the daily protein intake to 0.8–1.0 g per kg body weight. Diet modifications should begin early, i.e., even in patients with moderate kidney impairment, because usual dietary habits of many developed societies contribute an increased proportion of acid equivalents due to the high intake of protein from animal sources. |
topic |
metabolic acidosis kidney disease urolithiasis urinary stones protein fruits vegetables bicarbonate alkali citrate |
url |
http://www.mdpi.com/2072-6643/10/4/512 |
work_keys_str_mv |
AT roswithasiener dietarytreatmentofmetabolicacidosisinchronickidneydisease |
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