Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome
Metabolic syndrome (MetS) is a clinical manifestation characterized by a plethora of comorbidities, including hyperglycemia, abdominal obesity, arterial hypertension, and dyslipidemia. All MetS comorbidities participate to induce a low-grade inflammation state and oxidative stress, typical of this s...
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doaj-9f4bbebaac634a49b3f67d8bd71716bd2021-02-17T00:00:04ZengMDPI AGNutrients2072-66432021-02-011363063010.3390/nu13020630Natural Bioactive Compounds Useful in Clinical Management of Metabolic SyndromeAnnalisa Noce0Manuela Di Lauro1Francesca Di Daniele2Anna Pietroboni Zaitseva3Giulia Marrone4Patrizia Borboni5Nicola Di Daniele6UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, ItalyUOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, ItalyUOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, ItalyUOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, ItalyUOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, ItalyUOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, ItalyMetabolic syndrome (MetS) is a clinical manifestation characterized by a plethora of comorbidities, including hyperglycemia, abdominal obesity, arterial hypertension, and dyslipidemia. All MetS comorbidities participate to induce a low-grade inflammation state and oxidative stress, typical of this syndrome. MetS is related to an increased risk of cardiovascular diseases and early death, with an important impact on health-care costs. For its clinic management a poly-pharmaceutical therapy is often required, but this can cause side effects and reduce the patient’s compliance. For this reason, finding a valid and alternative therapeutic strategy, natural and free of side effects, could represent a useful tool in the fight the MetS. In this context, the use of functional foods, and the assumption of natural bioactive compounds (NBCs), could exert beneficial effects on body weight, blood pressure and glucose metabolism control, on endothelial damage, on the improvement of lipid profile, on the inflammatory state, and on oxidative stress. This review focuses on the possible beneficial role of NBCs in the prevention and in the clinical management of MetS and its comorbidities.https://www.mdpi.com/2072-6643/13/2/630metabolic syndromenatural bioactive compoundsarterial hypertensiondiabetes mellitusdyslipidemialow-grade inflammatory state |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Annalisa Noce Manuela Di Lauro Francesca Di Daniele Anna Pietroboni Zaitseva Giulia Marrone Patrizia Borboni Nicola Di Daniele |
spellingShingle |
Annalisa Noce Manuela Di Lauro Francesca Di Daniele Anna Pietroboni Zaitseva Giulia Marrone Patrizia Borboni Nicola Di Daniele Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome Nutrients metabolic syndrome natural bioactive compounds arterial hypertension diabetes mellitus dyslipidemia low-grade inflammatory state |
author_facet |
Annalisa Noce Manuela Di Lauro Francesca Di Daniele Anna Pietroboni Zaitseva Giulia Marrone Patrizia Borboni Nicola Di Daniele |
author_sort |
Annalisa Noce |
title |
Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome |
title_short |
Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome |
title_full |
Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome |
title_fullStr |
Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome |
title_full_unstemmed |
Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome |
title_sort |
natural bioactive compounds useful in clinical management of metabolic syndrome |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-02-01 |
description |
Metabolic syndrome (MetS) is a clinical manifestation characterized by a plethora of comorbidities, including hyperglycemia, abdominal obesity, arterial hypertension, and dyslipidemia. All MetS comorbidities participate to induce a low-grade inflammation state and oxidative stress, typical of this syndrome. MetS is related to an increased risk of cardiovascular diseases and early death, with an important impact on health-care costs. For its clinic management a poly-pharmaceutical therapy is often required, but this can cause side effects and reduce the patient’s compliance. For this reason, finding a valid and alternative therapeutic strategy, natural and free of side effects, could represent a useful tool in the fight the MetS. In this context, the use of functional foods, and the assumption of natural bioactive compounds (NBCs), could exert beneficial effects on body weight, blood pressure and glucose metabolism control, on endothelial damage, on the improvement of lipid profile, on the inflammatory state, and on oxidative stress. This review focuses on the possible beneficial role of NBCs in the prevention and in the clinical management of MetS and its comorbidities. |
topic |
metabolic syndrome natural bioactive compounds arterial hypertension diabetes mellitus dyslipidemia low-grade inflammatory state |
url |
https://www.mdpi.com/2072-6643/13/2/630 |
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