Clustered functional domains for curves and corners in cortical area V4
The ventral visual pathway is crucially involved in integrating low-level visual features into complex representations for objects and scenes. At an intermediate stage of the ventral visual pathway, V4 plays a crucial role in supporting this transformation. Many V4 neurons are selective for shape se...
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doaj-9f647d760b784588acc259fd5741f42f2021-06-03T14:18:31ZengeLife Sciences Publications LtdeLife2050-084X2021-05-011010.7554/eLife.63798Clustered functional domains for curves and corners in cortical area V4Rundong Jiang0https://orcid.org/0000-0002-9217-0749Ian Max Andolina1https://orcid.org/0000-0001-9985-3414Ming Li2https://orcid.org/0000-0001-5173-1602Shiming Tang3https://orcid.org/0000-0003-0294-3259Peking University School of Life Sciences, Beijing, China; Peking-Tsinghua Center for Life Sciences, Beijing, China; IDG/McGovern Institute for Brain Research at Peking University, Beijing, China; Key Laboratory of Machine Perception (Ministry of Education), Peking University, Beijing, ChinaThe Center for Excellence in Brain Science and Intelligence Technology, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, ChinaBeijing Normal University Faculty of Psychology, Beijing, ChinaPeking University School of Life Sciences, Beijing, China; Peking-Tsinghua Center for Life Sciences, Beijing, China; IDG/McGovern Institute for Brain Research at Peking University, Beijing, China; Key Laboratory of Machine Perception (Ministry of Education), Peking University, Beijing, ChinaThe ventral visual pathway is crucially involved in integrating low-level visual features into complex representations for objects and scenes. At an intermediate stage of the ventral visual pathway, V4 plays a crucial role in supporting this transformation. Many V4 neurons are selective for shape segments like curves and corners; however, it remains unclear whether these neurons are organized into clustered functional domains, a structural motif common across other visual cortices. Using two-photon calcium imaging in awake macaques, we confirmed and localized cortical domains selective for curves or corners in V4. Single-cell resolution imaging confirmed that curve- or corner-selective neurons were spatially clustered into such domains. When tested with hexagonal-segment stimuli, we find that stimulus smoothness is the cardinal difference between curve and corner selectivity in V4. Combining cortical population responses with single-neuron analysis, our results reveal that curves and corners are encoded by neurons clustered into functional domains in V4. This functionally specific population architecture bridges the gap between the early and late cortices of the ventral pathway and may serve to facilitate complex object recognition.https://elifesciences.org/articles/63798curve/corner domainV4ventral visual pathwaymacaquetwo-photon imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rundong Jiang Ian Max Andolina Ming Li Shiming Tang |
spellingShingle |
Rundong Jiang Ian Max Andolina Ming Li Shiming Tang Clustered functional domains for curves and corners in cortical area V4 eLife curve/corner domain V4 ventral visual pathway macaque two-photon imaging |
author_facet |
Rundong Jiang Ian Max Andolina Ming Li Shiming Tang |
author_sort |
Rundong Jiang |
title |
Clustered functional domains for curves and corners in cortical area V4 |
title_short |
Clustered functional domains for curves and corners in cortical area V4 |
title_full |
Clustered functional domains for curves and corners in cortical area V4 |
title_fullStr |
Clustered functional domains for curves and corners in cortical area V4 |
title_full_unstemmed |
Clustered functional domains for curves and corners in cortical area V4 |
title_sort |
clustered functional domains for curves and corners in cortical area v4 |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2021-05-01 |
description |
The ventral visual pathway is crucially involved in integrating low-level visual features into complex representations for objects and scenes. At an intermediate stage of the ventral visual pathway, V4 plays a crucial role in supporting this transformation. Many V4 neurons are selective for shape segments like curves and corners; however, it remains unclear whether these neurons are organized into clustered functional domains, a structural motif common across other visual cortices. Using two-photon calcium imaging in awake macaques, we confirmed and localized cortical domains selective for curves or corners in V4. Single-cell resolution imaging confirmed that curve- or corner-selective neurons were spatially clustered into such domains. When tested with hexagonal-segment stimuli, we find that stimulus smoothness is the cardinal difference between curve and corner selectivity in V4. Combining cortical population responses with single-neuron analysis, our results reveal that curves and corners are encoded by neurons clustered into functional domains in V4. This functionally specific population architecture bridges the gap between the early and late cortices of the ventral pathway and may serve to facilitate complex object recognition. |
topic |
curve/corner domain V4 ventral visual pathway macaque two-photon imaging |
url |
https://elifesciences.org/articles/63798 |
work_keys_str_mv |
AT rundongjiang clusteredfunctionaldomainsforcurvesandcornersincorticalareav4 AT ianmaxandolina clusteredfunctionaldomainsforcurvesandcornersincorticalareav4 AT mingli clusteredfunctionaldomainsforcurvesandcornersincorticalareav4 AT shimingtang clusteredfunctionaldomainsforcurvesandcornersincorticalareav4 |
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