Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
Brown adipose thermogenesis increases energy expenditure and relies on uncoupling protein 1 (UCP1), however, UCP1 knock-out mice show resistance to diet-induced obesity at room temperature. Here, the authors show that this resistance relies on FGF21-signaling, inducing the browning of white adipose...
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Bibliographic Details
| Main Authors: |
Susanne Keipert,
Dominik Lutter,
Bjoern O. Schroeder,
Daniel Brandt,
Marcus Ståhlman,
Thomas Schwarzmayr,
Elisabeth Graf,
Helmut Fuchs,
Martin Hrabe de Angelis,
Matthias H. Tschöp,
Jan Rozman,
Martin Jastroch |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-14069-2
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