Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice

Brown adipose thermogenesis increases energy expenditure and relies on uncoupling protein 1 (UCP1), however, UCP1 knock-out mice show resistance to diet-induced obesity at room temperature. Here, the authors show that this resistance relies on FGF21-signaling, inducing the browning of white adipose...

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Main Authors:	Susanne Keipert, Dominik Lutter, Bjoern O. Schroeder, Daniel Brandt, Marcus Ståhlman, Thomas Schwarzmayr, Elisabeth Graf, Helmut Fuchs, Martin Hrabe de Angelis, Matthias H. Tschöp, Jan Rozman, Martin Jastroch
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-14069-2

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spelling	doaj-9f6878bc1fa4458ca06f077b004448cb2021-05-11T08:01:29ZengNature Publishing GroupNature Communications2041-17232020-01-0111111210.1038/s41467-019-14069-2Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient miceSusanne Keipert0Dominik Lutter1Bjoern O. Schroeder2Daniel Brandt3Marcus Ståhlman4Thomas Schwarzmayr5Elisabeth Graf6Helmut Fuchs7Martin Hrabe de Angelis8Matthias H. Tschöp9Jan Rozman10Martin Jastroch11Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Institute of Medicine, University of GothenburgInstitute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Institute of Medicine, University of GothenburgInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)German Center for Diabetes Research (DZD)Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)German Center for Diabetes Research (DZD)Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)Brown adipose thermogenesis increases energy expenditure and relies on uncoupling protein 1 (UCP1), however, UCP1 knock-out mice show resistance to diet-induced obesity at room temperature. Here, the authors show that this resistance relies on FGF21-signaling, inducing the browning of white adipose tissue.https://doi.org/10.1038/s41467-019-14069-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Susanne Keipert Dominik Lutter Bjoern O. Schroeder Daniel Brandt Marcus Ståhlman Thomas Schwarzmayr Elisabeth Graf Helmut Fuchs Martin Hrabe de Angelis Matthias H. Tschöp Jan Rozman Martin Jastroch
spellingShingle	Susanne Keipert Dominik Lutter Bjoern O. Schroeder Daniel Brandt Marcus Ståhlman Thomas Schwarzmayr Elisabeth Graf Helmut Fuchs Martin Hrabe de Angelis Matthias H. Tschöp Jan Rozman Martin Jastroch Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice Nature Communications
author_facet	Susanne Keipert Dominik Lutter Bjoern O. Schroeder Daniel Brandt Marcus Ståhlman Thomas Schwarzmayr Elisabeth Graf Helmut Fuchs Martin Hrabe de Angelis Matthias H. Tschöp Jan Rozman Martin Jastroch
author_sort	Susanne Keipert
title	Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
title_short	Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
title_full	Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
title_fullStr	Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
title_full_unstemmed	Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
title_sort	endogenous fgf21-signaling controls paradoxical obesity resistance of ucp1-deficient mice
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	Brown adipose thermogenesis increases energy expenditure and relies on uncoupling protein 1 (UCP1), however, UCP1 knock-out mice show resistance to diet-induced obesity at room temperature. Here, the authors show that this resistance relies on FGF21-signaling, inducing the browning of white adipose tissue.
url	https://doi.org/10.1038/s41467-019-14069-2
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Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice

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