Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this t...

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Main Authors: Andrey Maryandyshev, Emanuele Pontali, Simon Tiberi, Onno Akkerman, Shashank Ganatra, Tsetan Dorji Sadutshang, Jan-Willem Alffenaar, Rohit Amale, Jai Mullerpattan, Sonam Topgyal, Zarir Farokh Udwadia, Rosella Centis, Lia D’Ambrosio, Giovanni Sotgiu, Giovanni Battista Migliori
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2017-10-01
Series:Emerging Infectious Diseases
Subjects:
MDR-TB
XDR-TB
bedaquiline
delamanid
combination treatment
effectiveness
Online Access:https://wwwnc.cdc.gov/eid/article/23/10/17-0834_article
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spelling doaj-9f6c72ec93884d30a3be4f41e41208372020-11-25T02:34:11ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592017-10-0123101718172110.3201/eid2310.170834Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant TuberculosisAndrey MaryandyshevEmanuele PontaliSimon TiberiOnno AkkermanShashank GanatraTsetan Dorji SadutshangJan-Willem AlffenaarRohit AmaleJai MullerpattanSonam TopgyalZarir Farokh UdwadiaRosella CentisLia D’AmbrosioGiovanni SotgiuGiovanni Battista MiglioriWe report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.https://wwwnc.cdc.gov/eid/article/23/10/17-0834_articleMDR-TBXDR-TBbedaquilinedelamanidcombination treatmenteffectiveness
collection DOAJ
language English
format Article
sources DOAJ
author Andrey Maryandyshev
Emanuele Pontali
Simon Tiberi
Onno Akkerman
Shashank Ganatra
Tsetan Dorji Sadutshang
Jan-Willem Alffenaar
Rohit Amale
Jai Mullerpattan
Sonam Topgyal
Zarir Farokh Udwadia
Rosella Centis
Lia D’Ambrosio
Giovanni Sotgiu
Giovanni Battista Migliori
spellingShingle Andrey Maryandyshev
Emanuele Pontali
Simon Tiberi
Onno Akkerman
Shashank Ganatra
Tsetan Dorji Sadutshang
Jan-Willem Alffenaar
Rohit Amale
Jai Mullerpattan
Sonam Topgyal
Zarir Farokh Udwadia
Rosella Centis
Lia D’Ambrosio
Giovanni Sotgiu
Giovanni Battista Migliori
Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis
Emerging Infectious Diseases
MDR-TB
XDR-TB
bedaquiline
delamanid
combination treatment
effectiveness
author_facet Andrey Maryandyshev
Emanuele Pontali
Simon Tiberi
Onno Akkerman
Shashank Ganatra
Tsetan Dorji Sadutshang
Jan-Willem Alffenaar
Rohit Amale
Jai Mullerpattan
Sonam Topgyal
Zarir Farokh Udwadia
Rosella Centis
Lia D’Ambrosio
Giovanni Sotgiu
Giovanni Battista Migliori
author_sort Andrey Maryandyshev
title Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis
title_short Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis
title_full Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis
title_fullStr Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis
title_full_unstemmed Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis
title_sort bedaquiline and delamanid combination treatment of 5 patients with pulmonary extensively drug-resistant tuberculosis
publisher Centers for Disease Control and Prevention
series Emerging Infectious Diseases
issn 1080-6040
1080-6059
publishDate 2017-10-01
description We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.
topic MDR-TB
XDR-TB
bedaquiline
delamanid
combination treatment
effectiveness
url https://wwwnc.cdc.gov/eid/article/23/10/17-0834_article
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