Serum free thiols in type 2 diabetes mellitus: A prospective study
Aims: Oxidative stress is a driver in the development of type 2 diabetes (T2DM) complications. As thiols (R-SH) are oxidized by reactive oxygen and sulfur species, circulating concentrations may directly reflect systemic redox status. We hypothesized that high serum R-SH concentrations are a reflect...
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doaj-9f6ff6fd34ab4b46b58b7c7af78ba7162020-11-25T00:42:13ZengElsevierJournal of Clinical & Translational Endocrinology2214-62372019-06-0116Serum free thiols in type 2 diabetes mellitus: A prospective studyEmmelien E.M. Schillern0Andreas Pasch1Martin Feelisch2Femke Waanders3Steven H. Hendriks4Rik Mencke5Geert Harms6Klaas H. Groenier7Henk J.G. Bilo8Jan-Luuk Hillebrands9Harry van Goor10Peter R. van Dijk11University of Groningen, University Medical Centre, Department of Pathology and Medical Biology, Groningen, the NetherlandsUniversity of Bern, Department of Biomedical Research, Bern, SwitzerlandClinical & Experimental Sciences, Faculty of Medicine, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United KingdomIsala, Department of Internal Medicine, Zwolle, the NetherlandsIsala, Diabetes Centre, Zwolle, the NetherlandsUniversity of Groningen, University Medical Centre, Department of Pathology and Medical Biology, Groningen, the NetherlandsUniversity of Groningen, University Medical Centre, Department of Pathology and Medical Biology, Groningen, the NetherlandsIsala, Diabetes Centre, Zwolle, the NetherlandsIsala, Department of Internal Medicine, Zwolle, the Netherlands; Isala, Diabetes Centre, Zwolle, the Netherlands; University of Groningen, University Medical Centre, Department of Internal Medicine, Groningen, the NetherlandsUniversity of Groningen, University Medical Centre, Department of Pathology and Medical Biology, Groningen, the NetherlandsUniversity of Groningen, University Medical Centre, Department of Pathology and Medical Biology, Groningen, the NetherlandsIsala, Diabetes Centre, Zwolle, the Netherlands; University of Groningen, University Medical Centre, Department of Internal Medicine, Groningen, the Netherlands; Corresponding author at: University of Groningen, University Medical Centre, Department of Internal Medicine. Hanzeplein 1, 9700 RB, HP AA41 Groningen, the Netherlands.Aims: Oxidative stress is a driver in the development of type 2 diabetes (T2DM) complications. As thiols (R-SH) are oxidized by reactive oxygen and sulfur species, circulating concentrations may directly reflect systemic redox status. We hypothesized that high serum R-SH concentrations are a reflection of a favourable redox status and may therefore positively associate with disease status. Methods: R-SH were measured in serum of 943 T2DM outpatients (55% males, 65 years and HbA1c of 6.7% (50 mmol/mol)) with a follow-up period of 1.2 years. Results: In the highest R-SH tertile patients were younger, more often men, had less microvascular complications, lower HbA1c and were more often treated nutritionally or with oral glucose-lowering drugs. Age- and sex adjusted hazard ratios for developing micro-, macro- or any complication plus death were 0.994, 0.992 and 0.993: even after adjustment for potential confounders. The Harrell’s C statistic to predict microvascular complications or any complication plus death was higher in the models with R-SH than in those without R-SH. Conclusions: Although R-SH concentrations were associated with a favourable disease status, it did not add to the predictive capacity for long-term complications. Based on the current data R-SH seems unsuitable as a prognostic marker in T2DM. Keywords: Type 2 diabetes, Glycemia, Oxidative stress, Thiols, Free sulfhydrylhttp://www.sciencedirect.com/science/article/pii/S2214623718301364 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Emmelien E.M. Schillern Andreas Pasch Martin Feelisch Femke Waanders Steven H. Hendriks Rik Mencke Geert Harms Klaas H. Groenier Henk J.G. Bilo Jan-Luuk Hillebrands Harry van Goor Peter R. van Dijk |
spellingShingle |
Emmelien E.M. Schillern Andreas Pasch Martin Feelisch Femke Waanders Steven H. Hendriks Rik Mencke Geert Harms Klaas H. Groenier Henk J.G. Bilo Jan-Luuk Hillebrands Harry van Goor Peter R. van Dijk Serum free thiols in type 2 diabetes mellitus: A prospective study Journal of Clinical & Translational Endocrinology |
author_facet |
Emmelien E.M. Schillern Andreas Pasch Martin Feelisch Femke Waanders Steven H. Hendriks Rik Mencke Geert Harms Klaas H. Groenier Henk J.G. Bilo Jan-Luuk Hillebrands Harry van Goor Peter R. van Dijk |
author_sort |
Emmelien E.M. Schillern |
title |
Serum free thiols in type 2 diabetes mellitus: A prospective study |
title_short |
Serum free thiols in type 2 diabetes mellitus: A prospective study |
title_full |
Serum free thiols in type 2 diabetes mellitus: A prospective study |
title_fullStr |
Serum free thiols in type 2 diabetes mellitus: A prospective study |
title_full_unstemmed |
Serum free thiols in type 2 diabetes mellitus: A prospective study |
title_sort |
serum free thiols in type 2 diabetes mellitus: a prospective study |
publisher |
Elsevier |
series |
Journal of Clinical & Translational Endocrinology |
issn |
2214-6237 |
publishDate |
2019-06-01 |
description |
Aims: Oxidative stress is a driver in the development of type 2 diabetes (T2DM) complications. As thiols (R-SH) are oxidized by reactive oxygen and sulfur species, circulating concentrations may directly reflect systemic redox status. We hypothesized that high serum R-SH concentrations are a reflection of a favourable redox status and may therefore positively associate with disease status. Methods: R-SH were measured in serum of 943 T2DM outpatients (55% males, 65 years and HbA1c of 6.7% (50 mmol/mol)) with a follow-up period of 1.2 years. Results: In the highest R-SH tertile patients were younger, more often men, had less microvascular complications, lower HbA1c and were more often treated nutritionally or with oral glucose-lowering drugs. Age- and sex adjusted hazard ratios for developing micro-, macro- or any complication plus death were 0.994, 0.992 and 0.993: even after adjustment for potential confounders. The Harrell’s C statistic to predict microvascular complications or any complication plus death was higher in the models with R-SH than in those without R-SH. Conclusions: Although R-SH concentrations were associated with a favourable disease status, it did not add to the predictive capacity for long-term complications. Based on the current data R-SH seems unsuitable as a prognostic marker in T2DM. Keywords: Type 2 diabetes, Glycemia, Oxidative stress, Thiols, Free sulfhydryl |
url |
http://www.sciencedirect.com/science/article/pii/S2214623718301364 |
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