The Potential Role of Circulating Endothelial Cells and Endothelial Progenitor Cells in the Prediction of Left Ventricular Hypertrophy in Hypertensive Patients
BackgroundThe main aim of present study is to evaluate the potential role of circulating endothelial cells (CECs) and endothelial progenitor cells (CEPCs) – representing specific markers of endothelial damage, in the prediction of left ventricular hypertrophy (LVH) in hypertensive patients categoriz...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-08-01
|
Series: | Frontiers in Physiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.01005/full |
id |
doaj-9f8206ded6384316ae76ddc1262111d5 |
---|---|
record_format |
Article |
spelling |
doaj-9f8206ded6384316ae76ddc1262111d52020-11-25T00:54:31ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-08-011010.3389/fphys.2019.01005453013The Potential Role of Circulating Endothelial Cells and Endothelial Progenitor Cells in the Prediction of Left Ventricular Hypertrophy in Hypertensive PatientsMagdalena Budzyń0Bogna Gryszczyńka1Maciej Boruczkowski2Mariusz Kaczmarek3Beata Begier-Krasińska4Angelika Osińska5Alicja Bukowska6Maria Iskra7Magdalena Paulina Kasprzak8Department of General Chemistry, Chair of Chemistry and Clinical Biochemistry, Poznań University of Medical Sciences, Poznań, PolandDepartment of General Chemistry, Chair of Chemistry and Clinical Biochemistry, Poznań University of Medical Sciences, Poznań, PolandDepartment of Clinical Immunology, Poznań University of Medical Sciences, Poznań, PolandDepartment of Clinical Immunology, Poznań University of Medical Sciences, Poznań, PolandDepartment of Hypertensiology, Angiology, and Internal Diseases, Poznań University of Medical Sciences, Poznań, PolandDepartment of Hypertensiology, Angiology, and Internal Diseases, Poznań University of Medical Sciences, Poznań, PolandMedical Analysis Laboratory, Regional Blood Center, Poznań, PolandDepartment of General Chemistry, Chair of Chemistry and Clinical Biochemistry, Poznań University of Medical Sciences, Poznań, PolandDepartment of General Chemistry, Chair of Chemistry and Clinical Biochemistry, Poznań University of Medical Sciences, Poznań, PolandBackgroundThe main aim of present study is to evaluate the potential role of circulating endothelial cells (CECs) and endothelial progenitor cells (CEPCs) – representing specific markers of endothelial damage, in the prediction of left ventricular hypertrophy (LVH) in hypertensive patients categorized into two groups; mild (MH) and resistant hypertension (RH).Materials and MethodsThirty patients with MH and 28 subjects with RH were involved in the study. In both groups, patients were divided into an LVH and non-LVH group. The control group included 33 age and sex-matched normotensive volunteers. Physical examination, laboratory tests and echocardiography were conducted.ResultsIn both the MH and RH group, patients with as well as without LVH demonstrated a higher number of CECs and a lower ratio of CEPCs/CECs as compared to the healthy control. Multiple linear regression analysis showed a positive association of CEPCs with left ventricular mass (LVM) and left ventricular mass index (LVMI), independently of other confounders.ConclusionOur results suggest that endothelial injury observed as an elevated CECs number and its impaired regeneration, reflected by a lowered CEPCs/CECs ratio, precede LVH occurrence and may play a significant role in LVH development regardless of the clinical severity of hypertension. Moreover, independent correlation of CEPCs with echocardiographic (ECG) incidences of LVH suggests their potential use as a screening biomarker to stratify the risk of LVH development.https://www.frontiersin.org/article/10.3389/fphys.2019.01005/fullleft ventricular hypertrophyhypertensioncirculating endothelial cellsendothelial progenitor cellsendothelial dysfunctionheart |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Magdalena Budzyń Bogna Gryszczyńka Maciej Boruczkowski Mariusz Kaczmarek Beata Begier-Krasińska Angelika Osińska Alicja Bukowska Maria Iskra Magdalena Paulina Kasprzak |
spellingShingle |
Magdalena Budzyń Bogna Gryszczyńka Maciej Boruczkowski Mariusz Kaczmarek Beata Begier-Krasińska Angelika Osińska Alicja Bukowska Maria Iskra Magdalena Paulina Kasprzak The Potential Role of Circulating Endothelial Cells and Endothelial Progenitor Cells in the Prediction of Left Ventricular Hypertrophy in Hypertensive Patients Frontiers in Physiology left ventricular hypertrophy hypertension circulating endothelial cells endothelial progenitor cells endothelial dysfunction heart |
author_facet |
Magdalena Budzyń Bogna Gryszczyńka Maciej Boruczkowski Mariusz Kaczmarek Beata Begier-Krasińska Angelika Osińska Alicja Bukowska Maria Iskra Magdalena Paulina Kasprzak |
author_sort |
Magdalena Budzyń |
title |
The Potential Role of Circulating Endothelial Cells and Endothelial Progenitor Cells in the Prediction of Left Ventricular Hypertrophy in Hypertensive Patients |
title_short |
The Potential Role of Circulating Endothelial Cells and Endothelial Progenitor Cells in the Prediction of Left Ventricular Hypertrophy in Hypertensive Patients |
title_full |
The Potential Role of Circulating Endothelial Cells and Endothelial Progenitor Cells in the Prediction of Left Ventricular Hypertrophy in Hypertensive Patients |
title_fullStr |
The Potential Role of Circulating Endothelial Cells and Endothelial Progenitor Cells in the Prediction of Left Ventricular Hypertrophy in Hypertensive Patients |
title_full_unstemmed |
The Potential Role of Circulating Endothelial Cells and Endothelial Progenitor Cells in the Prediction of Left Ventricular Hypertrophy in Hypertensive Patients |
title_sort |
potential role of circulating endothelial cells and endothelial progenitor cells in the prediction of left ventricular hypertrophy in hypertensive patients |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2019-08-01 |
description |
BackgroundThe main aim of present study is to evaluate the potential role of circulating endothelial cells (CECs) and endothelial progenitor cells (CEPCs) – representing specific markers of endothelial damage, in the prediction of left ventricular hypertrophy (LVH) in hypertensive patients categorized into two groups; mild (MH) and resistant hypertension (RH).Materials and MethodsThirty patients with MH and 28 subjects with RH were involved in the study. In both groups, patients were divided into an LVH and non-LVH group. The control group included 33 age and sex-matched normotensive volunteers. Physical examination, laboratory tests and echocardiography were conducted.ResultsIn both the MH and RH group, patients with as well as without LVH demonstrated a higher number of CECs and a lower ratio of CEPCs/CECs as compared to the healthy control. Multiple linear regression analysis showed a positive association of CEPCs with left ventricular mass (LVM) and left ventricular mass index (LVMI), independently of other confounders.ConclusionOur results suggest that endothelial injury observed as an elevated CECs number and its impaired regeneration, reflected by a lowered CEPCs/CECs ratio, precede LVH occurrence and may play a significant role in LVH development regardless of the clinical severity of hypertension. Moreover, independent correlation of CEPCs with echocardiographic (ECG) incidences of LVH suggests their potential use as a screening biomarker to stratify the risk of LVH development. |
topic |
left ventricular hypertrophy hypertension circulating endothelial cells endothelial progenitor cells endothelial dysfunction heart |
url |
https://www.frontiersin.org/article/10.3389/fphys.2019.01005/full |
work_keys_str_mv |
AT magdalenabudzyn thepotentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT bognagryszczynka thepotentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT maciejboruczkowski thepotentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT mariuszkaczmarek thepotentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT beatabegierkrasinska thepotentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT angelikaosinska thepotentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT alicjabukowska thepotentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT mariaiskra thepotentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT magdalenapaulinakasprzak thepotentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT magdalenabudzyn potentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT bognagryszczynka potentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT maciejboruczkowski potentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT mariuszkaczmarek potentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT beatabegierkrasinska potentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT angelikaosinska potentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT alicjabukowska potentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT mariaiskra potentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients AT magdalenapaulinakasprzak potentialroleofcirculatingendothelialcellsandendothelialprogenitorcellsinthepredictionofleftventricularhypertrophyinhypertensivepatients |
_version_ |
1725234009236045824 |