Hepatitis C Virus Subtypes Novel 6g-Related Subtype and 6w Could Be Indigenous in Southern Taiwan with Characteristic Geographic Distribution
Hepatitis C virus (HCV) genotype (GT) 6 is the most genetically diverse GT and mainly distributed in Southeast Asia and south China but not Taiwan. Earlier studies showed the major HCV GTs in Taiwan were GT 1b and 2 with very rare GT 6 except in injection drug users (IDUs), and subtype 6a is the mai...
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doaj-9f8ce8273df6407f9d02ceeb4bf9a6332021-07-23T14:11:31ZengMDPI AGViruses1999-49152021-07-01131316131610.3390/v13071316Hepatitis C Virus Subtypes Novel 6g-Related Subtype and 6w Could Be Indigenous in Southern Taiwan with Characteristic Geographic DistributionHung-Da Tung0Pei-Lun Lee1Jyh-Jou Chen2Hsing-Tao Kuo3Ming-Jen Sheu4Chun-Ta Cheng5Tang-Wei Chuang6Hsu-Ju Kao7Yu-Hsun Wu8Mai-Gio Pang9Cheng-Heng Lin10Chia-Yi Hou11Hsin-Hua Tsai12Li-Ching Wu13Chuan Lee14Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Yongkang, Tainan 71004, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Yongkang, Tainan 71004, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, TaiwanDepartment of Clinical Pathology, Chi-Mei Medical Center, Liouying, Tainan 73657, TaiwanDepartment of Clinical Pathology, Chi-Mei Medical Center, Yongkang, Tainan 71004, TaiwanDepartment of Clinical Pathology, Chi-Mei Medical Center, Yongkang, Tainan 71004, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Hospital, Chiali, Tainan 72263, TaiwanHepatitis C virus (HCV) genotype (GT) 6 is the most genetically diverse GT and mainly distributed in Southeast Asia and south China but not Taiwan. Earlier studies showed the major HCV GTs in Taiwan were GT 1b and 2 with very rare GT 6 except in injection drug users (IDUs), and subtype 6a is the main GT 6 subtype among IDUs. Recently, we reported a much higher prevalence (18.3%) of GT 6 in Tainan City, southern Taiwan. This study was designed to clarify the subtypes of GT 6 in this endemic area. A total of 3022 (1343 men and 1679 women) HCV viremic patients were enrolled. Subtypes of GT 6 were determined by sequencing of core/E1 and nonstructural protein 5B in 322 of 518 GT 6 patients. The overall GT 6 prevalence rate was 17.1% (518/3022), with higher prevalence districts (>25%) located in northern Tainan. A novel 6g-related subtype is the most prevalent subtype (81.0%), followed by 6w (10.8%), 6a (7.5%), and 6n (0.7%). The high GT 6 prevalence in Tainan was mainly due to a novel 6g-related subtype and 6w. These two subtypes could be indigenous in Tainan with characteristic geographic distribution.https://www.mdpi.com/1999-4915/13/7/1316hepatitis C virusgenotypeinjection drug userphylogenetic analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hung-Da Tung Pei-Lun Lee Jyh-Jou Chen Hsing-Tao Kuo Ming-Jen Sheu Chun-Ta Cheng Tang-Wei Chuang Hsu-Ju Kao Yu-Hsun Wu Mai-Gio Pang Cheng-Heng Lin Chia-Yi Hou Hsin-Hua Tsai Li-Ching Wu Chuan Lee |
spellingShingle |
Hung-Da Tung Pei-Lun Lee Jyh-Jou Chen Hsing-Tao Kuo Ming-Jen Sheu Chun-Ta Cheng Tang-Wei Chuang Hsu-Ju Kao Yu-Hsun Wu Mai-Gio Pang Cheng-Heng Lin Chia-Yi Hou Hsin-Hua Tsai Li-Ching Wu Chuan Lee Hepatitis C Virus Subtypes Novel 6g-Related Subtype and 6w Could Be Indigenous in Southern Taiwan with Characteristic Geographic Distribution Viruses hepatitis C virus genotype injection drug user phylogenetic analysis |
author_facet |
Hung-Da Tung Pei-Lun Lee Jyh-Jou Chen Hsing-Tao Kuo Ming-Jen Sheu Chun-Ta Cheng Tang-Wei Chuang Hsu-Ju Kao Yu-Hsun Wu Mai-Gio Pang Cheng-Heng Lin Chia-Yi Hou Hsin-Hua Tsai Li-Ching Wu Chuan Lee |
author_sort |
Hung-Da Tung |
title |
Hepatitis C Virus Subtypes Novel 6g-Related Subtype and 6w Could Be Indigenous in Southern Taiwan with Characteristic Geographic Distribution |
title_short |
Hepatitis C Virus Subtypes Novel 6g-Related Subtype and 6w Could Be Indigenous in Southern Taiwan with Characteristic Geographic Distribution |
title_full |
Hepatitis C Virus Subtypes Novel 6g-Related Subtype and 6w Could Be Indigenous in Southern Taiwan with Characteristic Geographic Distribution |
title_fullStr |
Hepatitis C Virus Subtypes Novel 6g-Related Subtype and 6w Could Be Indigenous in Southern Taiwan with Characteristic Geographic Distribution |
title_full_unstemmed |
Hepatitis C Virus Subtypes Novel 6g-Related Subtype and 6w Could Be Indigenous in Southern Taiwan with Characteristic Geographic Distribution |
title_sort |
hepatitis c virus subtypes novel 6g-related subtype and 6w could be indigenous in southern taiwan with characteristic geographic distribution |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2021-07-01 |
description |
Hepatitis C virus (HCV) genotype (GT) 6 is the most genetically diverse GT and mainly distributed in Southeast Asia and south China but not Taiwan. Earlier studies showed the major HCV GTs in Taiwan were GT 1b and 2 with very rare GT 6 except in injection drug users (IDUs), and subtype 6a is the main GT 6 subtype among IDUs. Recently, we reported a much higher prevalence (18.3%) of GT 6 in Tainan City, southern Taiwan. This study was designed to clarify the subtypes of GT 6 in this endemic area. A total of 3022 (1343 men and 1679 women) HCV viremic patients were enrolled. Subtypes of GT 6 were determined by sequencing of core/E1 and nonstructural protein 5B in 322 of 518 GT 6 patients. The overall GT 6 prevalence rate was 17.1% (518/3022), with higher prevalence districts (>25%) located in northern Tainan. A novel 6g-related subtype is the most prevalent subtype (81.0%), followed by 6w (10.8%), 6a (7.5%), and 6n (0.7%). The high GT 6 prevalence in Tainan was mainly due to a novel 6g-related subtype and 6w. These two subtypes could be indigenous in Tainan with characteristic geographic distribution. |
topic |
hepatitis C virus genotype injection drug user phylogenetic analysis |
url |
https://www.mdpi.com/1999-4915/13/7/1316 |
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