Latency associated peptide has in vitro and in vivo immune effects independent of TGF-beta1.

Latency associated peptide has in vitro and in vivo immune effects independent of TGF-beta1.

Latency Associated Peptide (LAP) binds TGF-beta1, forming a latent complex. Currently, LAP is presumed to function only as a sequestering agent for active TGF-beta1. Previous work shows that LAP can induce epithelial cell migration, but effects on leukocytes have not been reported. Because of the mu...

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Bibliographic Details
Main Authors: Naeem A Ali, Alice A Gaughan, Charles G Orosz, Chris P Baran, Sara McMaken, Yijie Wang, Timothy D Eubank, Melissa Hunter, Frank J Lichtenberger, Nicholas A Flavahan, Jack Lawler, Clay B Marsh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2288562?pdf=render

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