Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation
The effect of stevia on liver cirrhosis has not been previously investigated. In the present study, the antioxidant and anti-inflammatory properties of stevia leaves were studied in male Wistar rats with carbon tetrachloride- (CCl4-) induced acute and chronic liver damage. Acute and chronic liver da...
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2018/3823426 |
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doaj-9f962594d4eb4778abd0d738280264342020-11-24T22:38:57ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942018-01-01201810.1155/2018/38234263823426Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 UpregulationErika Ramos-Tovar0Erika Hernández-Aquino1Sael Casas-Grajales2Laura D. Buendia-Montaño3Silvia Galindo-Gómez4Javier Camacho5Víctor Tsutsumi6Pablo Muriel7Laboratory of Experimental Hepatology, Department of Pharmacology, CINVESTAV-IPN, Apartado Postal 14-740 Mexico City, MexicoLaboratory of Experimental Hepatology, Department of Pharmacology, CINVESTAV-IPN, Apartado Postal 14-740 Mexico City, MexicoLaboratory of Experimental Hepatology, Department of Pharmacology, CINVESTAV-IPN, Apartado Postal 14-740 Mexico City, MexicoLaboratory of Experimental Hepatology, Department of Pharmacology, CINVESTAV-IPN, Apartado Postal 14-740 Mexico City, MexicoDepartment of Infectomics and Molecular Pathogenesis, CINVESTAV-IPN, Apartado Postal 14-740 Mexico City, MexicoDepartment of Pharmacology, Apartado Postal, CINVESTAV-IPN, 14-740 Mexico City, MexicoDepartment of Infectomics and Molecular Pathogenesis, CINVESTAV-IPN, Apartado Postal 14-740 Mexico City, MexicoLaboratory of Experimental Hepatology, Department of Pharmacology, CINVESTAV-IPN, Apartado Postal 14-740 Mexico City, MexicoThe effect of stevia on liver cirrhosis has not been previously investigated. In the present study, the antioxidant and anti-inflammatory properties of stevia leaves were studied in male Wistar rats with carbon tetrachloride- (CCl4-) induced acute and chronic liver damage. Acute and chronic liver damage induced oxidative stress, necrosis, and cholestasis, which were significantly ameliorated by stevia. Chronic CCl4 treatment resulted in liver cirrhosis, as evidenced by nodules of hepatocytes surrounded by thick bands of collagen and distortion of the hepatic architecture, and stevia significantly prevented these alterations. Subsequently, the underlying mechanism of action of the plant was analyzed. Our study for the first time shows that stevia upregulated Nrf2, thereby counteracting oxidative stress, and prevented necrosis and cholestasis through modulation of the main proinflammatory cytokines via NF-κB inhibition. These multitarget mechanisms led to the prevention of experimental cirrhosis. Given the reasonable safety profile of stevia, our results indicated that it may be useful for the clinical treatment of acute and chronic liver diseases.http://dx.doi.org/10.1155/2018/3823426 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Erika Ramos-Tovar Erika Hernández-Aquino Sael Casas-Grajales Laura D. Buendia-Montaño Silvia Galindo-Gómez Javier Camacho Víctor Tsutsumi Pablo Muriel |
spellingShingle |
Erika Ramos-Tovar Erika Hernández-Aquino Sael Casas-Grajales Laura D. Buendia-Montaño Silvia Galindo-Gómez Javier Camacho Víctor Tsutsumi Pablo Muriel Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation Oxidative Medicine and Cellular Longevity |
author_facet |
Erika Ramos-Tovar Erika Hernández-Aquino Sael Casas-Grajales Laura D. Buendia-Montaño Silvia Galindo-Gómez Javier Camacho Víctor Tsutsumi Pablo Muriel |
author_sort |
Erika Ramos-Tovar |
title |
Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation |
title_short |
Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation |
title_full |
Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation |
title_fullStr |
Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation |
title_full_unstemmed |
Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation |
title_sort |
stevia prevents acute and chronic liver injury induced by carbon tetrachloride by blocking oxidative stress through nrf2 upregulation |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2018-01-01 |
description |
The effect of stevia on liver cirrhosis has not been previously investigated. In the present study, the antioxidant and anti-inflammatory properties of stevia leaves were studied in male Wistar rats with carbon tetrachloride- (CCl4-) induced acute and chronic liver damage. Acute and chronic liver damage induced oxidative stress, necrosis, and cholestasis, which were significantly ameliorated by stevia. Chronic CCl4 treatment resulted in liver cirrhosis, as evidenced by nodules of hepatocytes surrounded by thick bands of collagen and distortion of the hepatic architecture, and stevia significantly prevented these alterations. Subsequently, the underlying mechanism of action of the plant was analyzed. Our study for the first time shows that stevia upregulated Nrf2, thereby counteracting oxidative stress, and prevented necrosis and cholestasis through modulation of the main proinflammatory cytokines via NF-κB inhibition. These multitarget mechanisms led to the prevention of experimental cirrhosis. Given the reasonable safety profile of stevia, our results indicated that it may be useful for the clinical treatment of acute and chronic liver diseases. |
url |
http://dx.doi.org/10.1155/2018/3823426 |
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