Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression
Replication–transcription conflicts have been a well-studied source of genome instability for many years and have frequently been linked to defects in RNA processing. However, recent characterization of replication fork-associated proteins has revealed that defects in fork protection can directly or...
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doaj-9fa0f16442ff408fb9226a51c50047d82020-11-24T22:29:01ZengMDPI AGGenes2073-44252017-01-01813310.3390/genes8010033genes8010033Replication Fork Protection Factors Controlling R-Loop Bypass and SuppressionEmily Yun-Chia Chang0Peter C. Stirling1Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Ave., Vancouver, BC V5Z1L3, CanadaTerry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Ave., Vancouver, BC V5Z1L3, CanadaReplication–transcription conflicts have been a well-studied source of genome instability for many years and have frequently been linked to defects in RNA processing. However, recent characterization of replication fork-associated proteins has revealed that defects in fork protection can directly or indirectly stabilize R-loop structures in the genome and promote transcription–replication conflicts that lead to genome instability. Defects in essential DNA replication-associated activities like topoisomerase, or the minichromosome maintenance (MCM) helicase complex, as well as fork-associated protection factors like the Fanconi anemia pathway, both appear to mitigate transcription–replication conflicts. Here, we will highlight recent advances that support the concept that normal and robust replisome function itself is a key component of mitigating R-loop coupled genome instability.http://www.mdpi.com/2073-4425/8/1/33R-loopDNA replication stressDNA repairtranscription–replication conflict |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Emily Yun-Chia Chang Peter C. Stirling |
spellingShingle |
Emily Yun-Chia Chang Peter C. Stirling Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression Genes R-loop DNA replication stress DNA repair transcription–replication conflict |
author_facet |
Emily Yun-Chia Chang Peter C. Stirling |
author_sort |
Emily Yun-Chia Chang |
title |
Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression |
title_short |
Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression |
title_full |
Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression |
title_fullStr |
Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression |
title_full_unstemmed |
Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression |
title_sort |
replication fork protection factors controlling r-loop bypass and suppression |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2017-01-01 |
description |
Replication–transcription conflicts have been a well-studied source of genome instability for many years and have frequently been linked to defects in RNA processing. However, recent characterization of replication fork-associated proteins has revealed that defects in fork protection can directly or indirectly stabilize R-loop structures in the genome and promote transcription–replication conflicts that lead to genome instability. Defects in essential DNA replication-associated activities like topoisomerase, or the minichromosome maintenance (MCM) helicase complex, as well as fork-associated protection factors like the Fanconi anemia pathway, both appear to mitigate transcription–replication conflicts. Here, we will highlight recent advances that support the concept that normal and robust replisome function itself is a key component of mitigating R-loop coupled genome instability. |
topic |
R-loop DNA replication stress DNA repair transcription–replication conflict |
url |
http://www.mdpi.com/2073-4425/8/1/33 |
work_keys_str_mv |
AT emilyyunchiachang replicationforkprotectionfactorscontrollingrloopbypassandsuppression AT petercstirling replicationforkprotectionfactorscontrollingrloopbypassandsuppression |
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1725745238698360832 |