Clusterin as a potential marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy
Introduction: Carotid endarterectomy (CEA) is a surgical procedure used in the prevention of ischemic stroke. However, this procedure can cause complications of ischemia-reperfusion injury to the brain. Clusterin (CLU) is a cytoprotective chaperone protein that is released from neurons in response t...
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doaj-9fa89c4fe1694575b077b23276dceccb2021-04-02T13:21:25ZengUpsala Medical SocietyUpsala Journal of Medical Sciences0300-97342000-19672019-07-01124319319810.1080/03009734.2019.16463591646359Clusterin as a potential marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomyJoanna Iłżecka0Marek Iłżecki1Aneta Grabarska2Shawn Dave3Marcin Feldo4Tomasz Zubilewicz5Independent Neurological Rehabilitation Unit, Medical University of LublinMedical University of LublinMedical University of LublinUniversity of Oklahoma Health Sciences CenterMedical University of LublinMedical University of LublinIntroduction: Carotid endarterectomy (CEA) is a surgical procedure used in the prevention of ischemic stroke. However, this procedure can cause complications of ischemia-reperfusion injury to the brain. Clusterin (CLU) is a cytoprotective chaperone protein that is released from neurons in response to various neurological injuries. The objective of the study was to report the changes in serum CLU concentrations of patients undergoing CEA. Materials and methods: The study involved 25 patients with severe internal carotid artery stenosis. Serum samples were taken from patients at three different times: within 24 hours preoperatively to CEA, 12 hours postoperatively, and 48 hours postoperatively. Serum CLU concentrations were measured using a commercially available enzyme-linked immunosorbent assay. Results: When compared to concentrations preoperatively, the serum CLU concentration initially decreased during the 12 hours following CEA. However, 48 hours following the procedure there was an increase in the CLU concentration. After statistical analysis, differences were detected in serum CLU concentration between all three recorded measurements (P < 0.05). Conclusion: Data from our study indicate that serum CLU concentrations are affected after CEA. We hypothesize that serum CLU concentrations may depend on brain ischemia-reperfusion injury following this surgical procedure.http://dx.doi.org/10.1080/03009734.2019.1646359brain injurycarotid endarterectomyclusterinpotential markers |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joanna Iłżecka Marek Iłżecki Aneta Grabarska Shawn Dave Marcin Feldo Tomasz Zubilewicz |
spellingShingle |
Joanna Iłżecka Marek Iłżecki Aneta Grabarska Shawn Dave Marcin Feldo Tomasz Zubilewicz Clusterin as a potential marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy Upsala Journal of Medical Sciences brain injury carotid endarterectomy clusterin potential markers |
author_facet |
Joanna Iłżecka Marek Iłżecki Aneta Grabarska Shawn Dave Marcin Feldo Tomasz Zubilewicz |
author_sort |
Joanna Iłżecka |
title |
Clusterin as a potential marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy |
title_short |
Clusterin as a potential marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy |
title_full |
Clusterin as a potential marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy |
title_fullStr |
Clusterin as a potential marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy |
title_full_unstemmed |
Clusterin as a potential marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy |
title_sort |
clusterin as a potential marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy |
publisher |
Upsala Medical Society |
series |
Upsala Journal of Medical Sciences |
issn |
0300-9734 2000-1967 |
publishDate |
2019-07-01 |
description |
Introduction: Carotid endarterectomy (CEA) is a surgical procedure used in the prevention of ischemic stroke. However, this procedure can cause complications of ischemia-reperfusion injury to the brain. Clusterin (CLU) is a cytoprotective chaperone protein that is released from neurons in response to various neurological injuries. The objective of the study was to report the changes in serum CLU concentrations of patients undergoing CEA. Materials and methods: The study involved 25 patients with severe internal carotid artery stenosis. Serum samples were taken from patients at three different times: within 24 hours preoperatively to CEA, 12 hours postoperatively, and 48 hours postoperatively. Serum CLU concentrations were measured using a commercially available enzyme-linked immunosorbent assay. Results: When compared to concentrations preoperatively, the serum CLU concentration initially decreased during the 12 hours following CEA. However, 48 hours following the procedure there was an increase in the CLU concentration. After statistical analysis, differences were detected in serum CLU concentration between all three recorded measurements (P < 0.05). Conclusion: Data from our study indicate that serum CLU concentrations are affected after CEA. We hypothesize that serum CLU concentrations may depend on brain ischemia-reperfusion injury following this surgical procedure. |
topic |
brain injury carotid endarterectomy clusterin potential markers |
url |
http://dx.doi.org/10.1080/03009734.2019.1646359 |
work_keys_str_mv |
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