Contextualizing single‐arm trials with real‐world data: An emulated target trial comparing therapies for neovascular age‐related macular degeneration
Abstract One‐in‐four ophthalmology trials are single‐armed, which poses challenges to their interpretation. We demonstrate how real‐world cohorts used as external/synthetic control arms can contextualize such trials. We herein emulated a target trial on the intention‐to‐treat efficacy of off‐label b...
Main Authors: | Darren S. Thomas, Aaron Y. Lee, Philipp L. Müller, Roy Schwartz, Abraham Olvera‐Barrios, Alasdair N. Warwick, Praven J. Patel, Tjebo F.C. Heeren, Catherine Egan, Paul Taylor, Adnan Tufail, UK AMD EMR Users Group |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2021-05-01
|
Series: | Clinical and Translational Science |
Online Access: | https://doi.org/10.1111/cts.12974 |
Similar Items
-
Combination of ranibizumab and indomethacin for neovascular age-related macular degeneration: randomized controlled trial
by: Russo A, et al.
Published: (2018-03-01) -
Bevacizumab for neovascular age-related macular degeneration : clinical trial and repeatability of outcome measures
by: Patel, P. J.
Published: (2012) -
TANDEM TRIAL: a factorial randomised controlled trial of dose and review schedule of bevacizumab (Avastin) for neovascular macular degeneration in the East Midlands
by: Alan A Montgomery, et al.
Published: (2020-10-01) -
Anti-VEGF therapy of neovascular age-related macular degeneration: from randomized trials to routine clinical practice
by: R. R. Fayzrakhmanov
Published: (2019-06-01) -
Management of Neovascular Age-Related Macular Degeneration in Clinical Practice: Initiation, Maintenance, and Discontinuation of Therapy
by: Pearse A. Keane, et al.
Published: (2011-01-01)