NUAK2 is a critical YAP target in liver cancer
Hippo-YAP pathway plays an important role in cancers; however the in vivo relevance of YAP/TAZ target genes is unclear. Here, the authors show that NUAK2 is a target of YAP and participates in a feedback loop to maximize YAP activity. Inhibition of NUAK2 suppresses YAP-driven hepatomegaly and liver...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07394-5 |
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doaj-9fc9ce34002d427ca45e996eac694d2e |
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Article |
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doaj-9fc9ce34002d427ca45e996eac694d2e2021-05-11T10:04:38ZengNature Publishing GroupNature Communications2041-17232018-11-019111210.1038/s41467-018-07394-5NUAK2 is a critical YAP target in liver cancerWei-Chien Yuan0Brian Pepe-Mooney1Giorgio G. Galli2Michael T. Dill3Hai-Tsang Huang4Mingfeng Hao5Yumeng Wang6Han Liang7Raffaele A. Calogero8Fernando D. Camargo9Stem Cell Program, Boston Children’s HospitalStem Cell Program, Boston Children’s HospitalStem Cell Program, Boston Children’s HospitalStem Cell Program, Boston Children’s HospitalDepartment of Cancer Biology, Dana-Farber Cancer InstituteDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer CenterDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer CenterDepartment of Biotechnology and Health Sciences, Molecular Biotechnology Center, University of TorinoStem Cell Program, Boston Children’s HospitalHippo-YAP pathway plays an important role in cancers; however the in vivo relevance of YAP/TAZ target genes is unclear. Here, the authors show that NUAK2 is a target of YAP and participates in a feedback loop to maximize YAP activity. Inhibition of NUAK2 suppresses YAP-driven hepatomegaly and liver cancer growth, offering a new target for cancer therapy.https://doi.org/10.1038/s41467-018-07394-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Wei-Chien Yuan Brian Pepe-Mooney Giorgio G. Galli Michael T. Dill Hai-Tsang Huang Mingfeng Hao Yumeng Wang Han Liang Raffaele A. Calogero Fernando D. Camargo |
| spellingShingle |
Wei-Chien Yuan Brian Pepe-Mooney Giorgio G. Galli Michael T. Dill Hai-Tsang Huang Mingfeng Hao Yumeng Wang Han Liang Raffaele A. Calogero Fernando D. Camargo NUAK2 is a critical YAP target in liver cancer Nature Communications |
| author_facet |
Wei-Chien Yuan Brian Pepe-Mooney Giorgio G. Galli Michael T. Dill Hai-Tsang Huang Mingfeng Hao Yumeng Wang Han Liang Raffaele A. Calogero Fernando D. Camargo |
| author_sort |
Wei-Chien Yuan |
| title |
NUAK2 is a critical YAP target in liver cancer |
| title_short |
NUAK2 is a critical YAP target in liver cancer |
| title_full |
NUAK2 is a critical YAP target in liver cancer |
| title_fullStr |
NUAK2 is a critical YAP target in liver cancer |
| title_full_unstemmed |
NUAK2 is a critical YAP target in liver cancer |
| title_sort |
nuak2 is a critical yap target in liver cancer |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-11-01 |
| description |
Hippo-YAP pathway plays an important role in cancers; however the in vivo relevance of YAP/TAZ target genes is unclear. Here, the authors show that NUAK2 is a target of YAP and participates in a feedback loop to maximize YAP activity. Inhibition of NUAK2 suppresses YAP-driven hepatomegaly and liver cancer growth, offering a new target for cancer therapy. |
| url |
https://doi.org/10.1038/s41467-018-07394-5 |
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