NUAK2 is a critical YAP target in liver cancer
Hippo-YAP pathway plays an important role in cancers; however the in vivo relevance of YAP/TAZ target genes is unclear. Here, the authors show that NUAK2 is a target of YAP and participates in a feedback loop to maximize YAP activity. Inhibition of NUAK2 suppresses YAP-driven hepatomegaly and liver...
Main Authors: | Wei-Chien Yuan, Brian Pepe-Mooney, Giorgio G. Galli, Michael T. Dill, Hai-Tsang Huang, Mingfeng Hao, Yumeng Wang, Han Liang, Raffaele A. Calogero, Fernando D. Camargo |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-11-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-07394-5 |
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