Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker
Introduction: Multiple Sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As Myelin Basic Protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP in serum, stimulated, and unstimulated saliva...
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Iran University of Medical Sciences
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doaj-9fdb0e78d57a458bbf77ebacc6be7b2d2021-08-16T11:28:30ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422021-05-01123309314Serum and Saliva Myelin Basic Protein as Multiple Sclerosis BiomarkerMohammad Hossein Mirzaii-Dizgah0Mohammad Reza Mirzaii-Dizgah1Iraj Mirzaii-Dizgah2 Student Research Committee, School of Dentistry, AJA University of Medical Sciences, Tehran, Iran. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran. Introduction: Multiple Sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As Myelin Basic Protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP in serum, stimulated, and unstimulated saliva as a suitable biomarker for detecting MS. Methods: A case-control study was performed in 29 healthy women and 32 definitive relapsing-remitting MS patients hospitalized in Imam Reza hospital, Tehran, Iran. MBP level was assayed in serum and stimulated and unstimulated whole saliva. Results: MBP was expressed at a lower level in serum and stimulated saliva of MS patients compared to the control group. The serum MBP level had a considerable correlation with its stimulated saliva level. The receiver operating characteristic analysis showed significant diagnostic ability for MBP to discriminate MS patients with serum and stimulated saliva from controls. Conclusion: Serum and saliva level of MBP is lower in MS, so it may be considered a potential biomarker in MS.http://bcn.iums.ac.ir/article-1-1573-en.htmlmultiple sclerosismyelin basic proteinsalivaserum |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Hossein Mirzaii-Dizgah Mohammad Reza Mirzaii-Dizgah Iraj Mirzaii-Dizgah |
spellingShingle |
Mohammad Hossein Mirzaii-Dizgah Mohammad Reza Mirzaii-Dizgah Iraj Mirzaii-Dizgah Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker Basic and Clinical Neuroscience multiple sclerosis myelin basic protein saliva serum |
author_facet |
Mohammad Hossein Mirzaii-Dizgah Mohammad Reza Mirzaii-Dizgah Iraj Mirzaii-Dizgah |
author_sort |
Mohammad Hossein Mirzaii-Dizgah |
title |
Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker |
title_short |
Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker |
title_full |
Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker |
title_fullStr |
Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker |
title_full_unstemmed |
Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker |
title_sort |
serum and saliva myelin basic protein as multiple sclerosis biomarker |
publisher |
Iran University of Medical Sciences |
series |
Basic and Clinical Neuroscience |
issn |
2008-126X 2228-7442 |
publishDate |
2021-05-01 |
description |
Introduction: Multiple Sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As Myelin Basic Protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP in serum, stimulated, and unstimulated saliva as a suitable biomarker for detecting MS.
Methods: A case-control study was performed in 29 healthy women and 32 definitive relapsing-remitting MS patients hospitalized in Imam Reza hospital, Tehran, Iran. MBP level was assayed in serum and stimulated and unstimulated whole saliva.
Results: MBP was expressed at a lower level in serum and stimulated saliva of MS patients compared to the control group. The serum MBP level had a considerable correlation with its stimulated saliva level. The receiver operating characteristic analysis showed significant diagnostic ability for MBP to discriminate MS patients with serum and stimulated saliva from controls.
Conclusion: Serum and saliva level of MBP is lower in MS, so it may be considered a potential biomarker in MS. |
topic |
multiple sclerosis myelin basic protein saliva serum |
url |
http://bcn.iums.ac.ir/article-1-1573-en.html |
work_keys_str_mv |
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