Regulation of Francisella tularensis Virulence
Francisella tularensis is one of the most virulent bacteria known and a Centers for Disease Control and Prevention Category A select agent. It is able to infect a variety of animals and insects and can persist in the environment, thus Francisella spp. must be able to survive in diverse environmental...
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2011-01-01
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2010.00144/full |
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doaj-9fe4e952cb2743b1b71566b2b7e93e442020-11-25T00:03:47ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882011-01-01110.3389/fmicb.2010.001448948Regulation of Francisella tularensis VirulenceShipan eDai0Nrusingh P Mohapatra1Larry S Schlesinger2Larry S Schlesinger3Larry S Schlesinger4John S Gunn5John S Gunn6John S Gunn7The Ohio State UniversityThe Ohio State UniversityThe Ohio State UniversityThe Ohio State UniversityThe Ohio State UniversityThe Ohio State UniversityThe Ohio State UniversityThe Ohio State UniversityFrancisella tularensis is one of the most virulent bacteria known and a Centers for Disease Control and Prevention Category A select agent. It is able to infect a variety of animals and insects and can persist in the environment, thus Francisella spp. must be able to survive in diverse environmental niches. However, F. tularensis has a surprising dearth of sensory and regulatory factors. Recent advancements in the field have identified new functions of encoded transcription factors and greatly expanded our understanding of virulence gene regulation. Here we review the current knowledge of environmental adaptation by F. tularensis, its transcriptional regulators and their relationship to animal virulence.http://journal.frontiersin.org/Journal/10.3389/fmicb.2010.00144/fullFrancisellaFrancisella Pathogenicity Island (FPI)transcriptional regulatorstwo-component regulatory systems (TCS) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shipan eDai Nrusingh P Mohapatra Larry S Schlesinger Larry S Schlesinger Larry S Schlesinger John S Gunn John S Gunn John S Gunn |
spellingShingle |
Shipan eDai Nrusingh P Mohapatra Larry S Schlesinger Larry S Schlesinger Larry S Schlesinger John S Gunn John S Gunn John S Gunn Regulation of Francisella tularensis Virulence Frontiers in Cellular and Infection Microbiology Francisella Francisella Pathogenicity Island (FPI) transcriptional regulators two-component regulatory systems (TCS) |
author_facet |
Shipan eDai Nrusingh P Mohapatra Larry S Schlesinger Larry S Schlesinger Larry S Schlesinger John S Gunn John S Gunn John S Gunn |
author_sort |
Shipan eDai |
title |
Regulation of Francisella tularensis Virulence |
title_short |
Regulation of Francisella tularensis Virulence |
title_full |
Regulation of Francisella tularensis Virulence |
title_fullStr |
Regulation of Francisella tularensis Virulence |
title_full_unstemmed |
Regulation of Francisella tularensis Virulence |
title_sort |
regulation of francisella tularensis virulence |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2011-01-01 |
description |
Francisella tularensis is one of the most virulent bacteria known and a Centers for Disease Control and Prevention Category A select agent. It is able to infect a variety of animals and insects and can persist in the environment, thus Francisella spp. must be able to survive in diverse environmental niches. However, F. tularensis has a surprising dearth of sensory and regulatory factors. Recent advancements in the field have identified new functions of encoded transcription factors and greatly expanded our understanding of virulence gene regulation. Here we review the current knowledge of environmental adaptation by F. tularensis, its transcriptional regulators and their relationship to animal virulence. |
topic |
Francisella Francisella Pathogenicity Island (FPI) transcriptional regulators two-component regulatory systems (TCS) |
url |
http://journal.frontiersin.org/Journal/10.3389/fmicb.2010.00144/full |
work_keys_str_mv |
AT shipanedai regulationoffrancisellatularensisvirulence AT nrusinghpmohapatra regulationoffrancisellatularensisvirulence AT larrysschlesinger regulationoffrancisellatularensisvirulence AT larrysschlesinger regulationoffrancisellatularensisvirulence AT larrysschlesinger regulationoffrancisellatularensisvirulence AT johnsgunn regulationoffrancisellatularensisvirulence AT johnsgunn regulationoffrancisellatularensisvirulence AT johnsgunn regulationoffrancisellatularensisvirulence |
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