PTK2 and PTPN11 expression in myelodysplastic syndromes
OBJECTIVE: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from...
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Faculdade de Medicina / USP
2013-10-01
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doaj-9fe68a1d08894c3a850349ce3334c5c12020-11-24T23:03:30ZengFaculdade de Medicina / USPClinics1980-53222013-10-0168101371137510.6061/clinics/2013(10)13S1807-59322013001001371PTK2 and PTPN11 expression in myelodysplastic syndromesMariana LazariniJoao Agostinho Machado-NetoLeticia Frohlich ArchangeloBruna Fernandes Mendes-SilvaCarolina Louzao BigarellaFabiola TrainaSara Teresinha Olalla SaadOBJECTIVE: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes. METHODS: Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions were analyzed by quantitative polymerase chain reaction in bone marrow cells from patients with myelodysplastic syndromes and healthy donors. RESULTS: Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions did not significantly differ between normal cells and myelodysplastic cells. CONCLUSIONS: Our data suggest that despite the relevance of focal adhesion kinase and src homology 2 domain-containing protein-tyrosine phosphatase 2 in hematopoietic disorders, their mRNA expression do not significantly differ between total bone marrow cells from patients with myelodysplastic syndromes and healthy donors.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013001001371&lng=en&tlng=enMyelodysplastic SyndromesPTPN11PTK2FAKSHP2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mariana Lazarini Joao Agostinho Machado-Neto Leticia Frohlich Archangelo Bruna Fernandes Mendes-Silva Carolina Louzao Bigarella Fabiola Traina Sara Teresinha Olalla Saad |
spellingShingle |
Mariana Lazarini Joao Agostinho Machado-Neto Leticia Frohlich Archangelo Bruna Fernandes Mendes-Silva Carolina Louzao Bigarella Fabiola Traina Sara Teresinha Olalla Saad PTK2 and PTPN11 expression in myelodysplastic syndromes Clinics Myelodysplastic Syndromes PTPN11 PTK2 FAK SHP2 |
author_facet |
Mariana Lazarini Joao Agostinho Machado-Neto Leticia Frohlich Archangelo Bruna Fernandes Mendes-Silva Carolina Louzao Bigarella Fabiola Traina Sara Teresinha Olalla Saad |
author_sort |
Mariana Lazarini |
title |
PTK2 and PTPN11 expression in myelodysplastic syndromes |
title_short |
PTK2 and PTPN11 expression in myelodysplastic syndromes |
title_full |
PTK2 and PTPN11 expression in myelodysplastic syndromes |
title_fullStr |
PTK2 and PTPN11 expression in myelodysplastic syndromes |
title_full_unstemmed |
PTK2 and PTPN11 expression in myelodysplastic syndromes |
title_sort |
ptk2 and ptpn11 expression in myelodysplastic syndromes |
publisher |
Faculdade de Medicina / USP |
series |
Clinics |
issn |
1980-5322 |
publishDate |
2013-10-01 |
description |
OBJECTIVE: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes. METHODS: Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions were analyzed by quantitative polymerase chain reaction in bone marrow cells from patients with myelodysplastic syndromes and healthy donors. RESULTS: Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions did not significantly differ between normal cells and myelodysplastic cells. CONCLUSIONS: Our data suggest that despite the relevance of focal adhesion kinase and src homology 2 domain-containing protein-tyrosine phosphatase 2 in hematopoietic disorders, their mRNA expression do not significantly differ between total bone marrow cells from patients with myelodysplastic syndromes and healthy donors. |
topic |
Myelodysplastic Syndromes PTPN11 PTK2 FAK SHP2 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013001001371&lng=en&tlng=en |
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