Esophageal Squamous Cell Carcinoma with Marked Eosinophil Infiltration

• Main Authors: Minoru Fukuchi, Shinji Sakurai, Masaki Suzuki, Hiroshi Naitoh, Yuichi Tabe, Takaharu Fukasawa, Shinsuke Kiriyama, Takehiko Yokobori, Hiroyuki Kuwano
• Format: Article
• Language: English
• Published: Karger Publishers 2011-11-01
• Series: Case Reports in Gastroenterology
• Subjects: Eosinophil infiltration; Esophageal squamous cell carcinoma; Esophagectomy
• Online Access: http://www.karger.com/Article/FullText/332441

We report a case of esophageal squamous cell carcinoma (SCC) with marked eosinophil infiltration which was identified postoperatively in the esophageal wall in areas not surrounding the SCC. The eosinophil infiltration was seen in the submucosa, muscle and adventitia, but not in the mucosa. Eosinophilic esophagitis (EoE) is a pathological condition defined as eosinophil infiltration within the esophageal mucosa. Eosinophil infiltration at the invasion front of esophageal SCC is termed tumor-associated tissue eosinophilia (TATE). However, the eosinophil infiltration in this case may be pathologically different from both EoE and TATE. To our knowledge, this is the first report of esophageal SCC with eosinophil infiltration.