Clinical Utility of the Detection of the Loss of the Mismatched HLA in Relapsed Hematological Patients After Haploidentical Stem Cell Transplantation With High-Dose Cyclophosphamide

Clinical Utility of the Detection of the Loss of the Mismatched HLA in Relapsed Hematological Patients After Haploidentical Stem Cell Transplantation With High-Dose Cyclophosphamide

Haploidentical hematopoietic stem cell transplantation (Haplo-HSCT) with high-dose cyclophosphamide (PTCy) has resulted in a low incidence of graft-vs.-host disease (GVHD), graft failure, and non-relapse mortality. However, post-transplantation relapse remains a common cause of treatment failure in...

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Bibliographic Details
Main Authors: Paula Muñiz, Mi Kwon, Diego Carbonell, María Chicano, Rebeca Bailén, Gillen Oarbeascoa, Julia Suárez-González, Cristina Andrés-Zayas, Javier Menárguez, Nieves Dorado, Ignacio Gómez-Centurión, Javier Anguita, José Luis Díez-Martín, Carolina Martínez-Laperche, Ismael Buño
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
HLA-loss
immune evasion
post-transplantation relapse
haploidentical stem cell transplantation
cyclophosphamide
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.642087/full

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