MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment
The tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here the authors show that radiation induced miR-103 downregulates TREX1 in endothelial cells, decreases angiogenesis and leads to the secretion of proinflammatory mediators that reduce tumour growth.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13597 |
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doaj-a01c9f15bea14236bb83264f01ebc4092021-05-11T10:55:39ZengNature Publishing GroupNature Communications2041-17232016-11-017111010.1038/ncomms13597MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironmentRaeAnna Wilson0Cristina Espinosa-Diez1Nathan Kanner2Namita Chatterjee3Rebecca Ruhl4Christina Hipfinger5Sunil J. Advani6Jie Li7Omar F. Khan8Aleksandra Franovic9Sara M. Weis10Sushil Kumar11Lisa M. Coussens12Daniel G. Anderson13Clark C. Chen14David A. Cheresh15Sudarshan Anand16Department of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science UniversityDepartment of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science UniversityDepartment of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science UniversityDepartment of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science UniversityDepartment of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science UniversityDepartment of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science UniversityDepartment of Radiation Medicine and Applied Sciences, University of CaliforniaDepartment of Neurosurgery, University of CaliforniaDepartment of Chemical Engineering, Institute for Medical Engineering and Science, David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of TechnologyDepartment of Pathology at the UC San Diego Moores Cancer Center and Sanford Consortium for Regenerative Medicine, University of CaliforniaDepartment of Pathology at the UC San Diego Moores Cancer Center and Sanford Consortium for Regenerative Medicine, University of CaliforniaDepartment of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science UniversityDepartment of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science UniversityDepartment of Chemical Engineering, Institute for Medical Engineering and Science, David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of TechnologyDepartment of Neurosurgery, University of CaliforniaDepartment of Pathology at the UC San Diego Moores Cancer Center and Sanford Consortium for Regenerative Medicine, University of CaliforniaDepartment of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science UniversityThe tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here the authors show that radiation induced miR-103 downregulates TREX1 in endothelial cells, decreases angiogenesis and leads to the secretion of proinflammatory mediators that reduce tumour growth.https://doi.org/10.1038/ncomms13597 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
RaeAnna Wilson Cristina Espinosa-Diez Nathan Kanner Namita Chatterjee Rebecca Ruhl Christina Hipfinger Sunil J. Advani Jie Li Omar F. Khan Aleksandra Franovic Sara M. Weis Sushil Kumar Lisa M. Coussens Daniel G. Anderson Clark C. Chen David A. Cheresh Sudarshan Anand |
| spellingShingle |
RaeAnna Wilson Cristina Espinosa-Diez Nathan Kanner Namita Chatterjee Rebecca Ruhl Christina Hipfinger Sunil J. Advani Jie Li Omar F. Khan Aleksandra Franovic Sara M. Weis Sushil Kumar Lisa M. Coussens Daniel G. Anderson Clark C. Chen David A. Cheresh Sudarshan Anand MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment Nature Communications |
| author_facet |
RaeAnna Wilson Cristina Espinosa-Diez Nathan Kanner Namita Chatterjee Rebecca Ruhl Christina Hipfinger Sunil J. Advani Jie Li Omar F. Khan Aleksandra Franovic Sara M. Weis Sushil Kumar Lisa M. Coussens Daniel G. Anderson Clark C. Chen David A. Cheresh Sudarshan Anand |
| author_sort |
RaeAnna Wilson |
| title |
MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment |
| title_short |
MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment |
| title_full |
MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment |
| title_fullStr |
MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment |
| title_full_unstemmed |
MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment |
| title_sort |
microrna regulation of endothelial trex1 reprograms the tumour microenvironment |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-11-01 |
| description |
The tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here the authors show that radiation induced miR-103 downregulates TREX1 in endothelial cells, decreases angiogenesis and leads to the secretion of proinflammatory mediators that reduce tumour growth. |
| url |
https://doi.org/10.1038/ncomms13597 |
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