Design, Synthesis and SAR Study of Novel Trisubstituted Pyrimidine Amide Derivatives as CCR4 Antagonists

Design, Synthesis and SAR Study of Novel Trisubstituted Pyrimidine Amide Derivatives as CCR4 Antagonists

The design, synthesis and structure-activity relationship studies of some novel trisubstituted pyrimidine amide derivatives prepared as CCR4 antagonists are described. The activities of these compounds were evaluated by the CCR4-MDC chemotaxis inhibition assay. Compound 1, which we have previously r...

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Bibliographic Details
Main Authors: Libao Xu, Yang Zhang, Wenjie Dai, Ying Wang, Dan Jiang, Lili Wang, Junhai Xiao, Xiaohong Yang, Song Li
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Molecules
Subjects:
antagonists
pyrimidine amides
synthesis
structure-activity relationship
Online Access:http://www.mdpi.com/1420-3049/19/3/3539

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