Correlation of serum betatrophin levels with disease severity and the emergence of insulin resistance in cirrhotic patients
Abstract Background Insulin resistance (IR) is frequently associated with chronic liver disease. There has been an increased interest in betatrophin protein and its involvement in the compensatory response to IR. We aimed to investigate the correlation of serum betatrophin levels with disease severi...
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doaj-a039e7b7d39c47b2a2727566ffb2be0e2020-11-25T02:42:13ZengSpringerOpenEgyptian Liver Journal2090-62262020-08-011011610.1186/s43066-020-00039-7Correlation of serum betatrophin levels with disease severity and the emergence of insulin resistance in cirrhotic patientsMohamed Magdy Salama0Walaa Ahmed Kabiel1Silvia Shoukry Hana2Ghada Abdelrahman Mohamed3Department of Internal Medicine, Gastroenterology and Hepatology Unit, Faculty of Medicine, Ain Shams UniversityDepartment of Clinical Pathology, Faculty of Medicine, Ain Shams UniversityDepartment of Internal Medicine, Gastroenterology and Hepatology Unit, Faculty of Medicine, Ain Shams UniversityDepartment of Internal Medicine, Gastroenterology and Hepatology Unit, Faculty of Medicine, Ain Shams UniversityAbstract Background Insulin resistance (IR) is frequently associated with chronic liver disease. There has been an increased interest in betatrophin protein and its involvement in the compensatory response to IR. We aimed to investigate the correlation of serum betatrophin levels with disease severity and the emergence of IR in cirrhotic patients. This study included 27 cirrhotic patients and 30 healthy participants who served as a control group. IR was assessed by the Homeostasis Model Assessment (HOMA-IR). Serum insulin and betatrophin levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA). Results IR was existing in 74% of cirrhotic patients (p < 0.001). Subjects with IR had higher serum betatrophin levels than those without IR (p = 0.04). Serum betatrophin levels were significantly higher in cirrhotic patients than controls (p < 0.001). In addition, Child-Pugh class C patients had higher serum betatrophin levels than those with Child-Pugh class B cirrhosis (p = 0.01). Moreover, the highest serum betatrophin levels were detected in patients with tense ascites followed by those with moderate and mild ascites (p = 0.01). In the cirrhosis group, serum betatrophin levels correlated positively with fasting blood glucose levels (p < 0.001), fasting insulin levels (p = 0.006), HOMA-IR (p = 0.006), Child-Pugh score (p = 0.023), MELD score (p < 0.001), and INR (p = 0.005), and correlated negatively with platelets count (p = 0.01). Conclusion Cirrhotic patients have higher serum betatrophin levels; moreover, these levels are positively correlated with disease severity as well as the emergence of insulin resistance.http://link.springer.com/article/10.1186/s43066-020-00039-7Liver cirrhosisInsulin resistanceHuman betatrophin protein |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohamed Magdy Salama Walaa Ahmed Kabiel Silvia Shoukry Hana Ghada Abdelrahman Mohamed |
spellingShingle |
Mohamed Magdy Salama Walaa Ahmed Kabiel Silvia Shoukry Hana Ghada Abdelrahman Mohamed Correlation of serum betatrophin levels with disease severity and the emergence of insulin resistance in cirrhotic patients Egyptian Liver Journal Liver cirrhosis Insulin resistance Human betatrophin protein |
author_facet |
Mohamed Magdy Salama Walaa Ahmed Kabiel Silvia Shoukry Hana Ghada Abdelrahman Mohamed |
author_sort |
Mohamed Magdy Salama |
title |
Correlation of serum betatrophin levels with disease severity and the emergence of insulin resistance in cirrhotic patients |
title_short |
Correlation of serum betatrophin levels with disease severity and the emergence of insulin resistance in cirrhotic patients |
title_full |
Correlation of serum betatrophin levels with disease severity and the emergence of insulin resistance in cirrhotic patients |
title_fullStr |
Correlation of serum betatrophin levels with disease severity and the emergence of insulin resistance in cirrhotic patients |
title_full_unstemmed |
Correlation of serum betatrophin levels with disease severity and the emergence of insulin resistance in cirrhotic patients |
title_sort |
correlation of serum betatrophin levels with disease severity and the emergence of insulin resistance in cirrhotic patients |
publisher |
SpringerOpen |
series |
Egyptian Liver Journal |
issn |
2090-6226 |
publishDate |
2020-08-01 |
description |
Abstract Background Insulin resistance (IR) is frequently associated with chronic liver disease. There has been an increased interest in betatrophin protein and its involvement in the compensatory response to IR. We aimed to investigate the correlation of serum betatrophin levels with disease severity and the emergence of IR in cirrhotic patients. This study included 27 cirrhotic patients and 30 healthy participants who served as a control group. IR was assessed by the Homeostasis Model Assessment (HOMA-IR). Serum insulin and betatrophin levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA). Results IR was existing in 74% of cirrhotic patients (p < 0.001). Subjects with IR had higher serum betatrophin levels than those without IR (p = 0.04). Serum betatrophin levels were significantly higher in cirrhotic patients than controls (p < 0.001). In addition, Child-Pugh class C patients had higher serum betatrophin levels than those with Child-Pugh class B cirrhosis (p = 0.01). Moreover, the highest serum betatrophin levels were detected in patients with tense ascites followed by those with moderate and mild ascites (p = 0.01). In the cirrhosis group, serum betatrophin levels correlated positively with fasting blood glucose levels (p < 0.001), fasting insulin levels (p = 0.006), HOMA-IR (p = 0.006), Child-Pugh score (p = 0.023), MELD score (p < 0.001), and INR (p = 0.005), and correlated negatively with platelets count (p = 0.01). Conclusion Cirrhotic patients have higher serum betatrophin levels; moreover, these levels are positively correlated with disease severity as well as the emergence of insulin resistance. |
topic |
Liver cirrhosis Insulin resistance Human betatrophin protein |
url |
http://link.springer.com/article/10.1186/s43066-020-00039-7 |
work_keys_str_mv |
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