Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma

Senescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation in an in vivo model of adamantinomatous craniophary...

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Main Authors: Jose Mario Gonzalez-Meljem, Scott Haston, Gabriela Carreno, John R. Apps, Sara Pozzi, Christina Stache, Grace Kaushal, Alex Virasami, Leonidas Panousopoulos, Seyedeh Neda Mousavy-Gharavy, Ana Guerrero, Mamunur Rashid, Nital Jani, Colin R. Goding, Thomas S. Jacques, David J. Adams, Jesus Gil, Cynthia L. Andoniadou, Juan Pedro Martinez-Barbera
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01992-5
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spelling doaj-a0474958863a4634a3e1c6faf8951dc52021-05-11T07:09:41ZengNature Publishing GroupNature Communications2041-17232017-11-018111410.1038/s41467-017-01992-5Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngiomaJose Mario Gonzalez-Meljem0Scott Haston1Gabriela Carreno2John R. Apps3Sara Pozzi4Christina Stache5Grace Kaushal6Alex Virasami7Leonidas Panousopoulos8Seyedeh Neda Mousavy-Gharavy9Ana Guerrero10Mamunur Rashid11Nital Jani12Colin R. Goding13Thomas S. Jacques14David J. Adams15Jesus Gil16Cynthia L. Andoniadou17Juan Pedro Martinez-Barbera18Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDepartment of Histopathology, Great Ormond Street Hospital for ChildrenDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthCell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, Du Cane RoadExperimental Cancer Genetics, Wellcome Trust Sanger Institute, HinxtonGOSgene, Genetics and Genomic Medicine, UCL Institute of Child HealthLudwig Institute for Cancer Research, Oxford University, Old Road Campus, HeadingtonDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthExperimental Cancer Genetics, Wellcome Trust Sanger Institute, HinxtonCell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, Du Cane RoadCentre for Craniofacial and Regenerative Biology, King’s College London, Guy’s Hospital, Floor 27 Tower WingDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthSenescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation in an in vivo model of adamantinomatous craniopharyngioma.https://doi.org/10.1038/s41467-017-01992-5
collection DOAJ
language English
format Article
sources DOAJ
author Jose Mario Gonzalez-Meljem
Scott Haston
Gabriela Carreno
John R. Apps
Sara Pozzi
Christina Stache
Grace Kaushal
Alex Virasami
Leonidas Panousopoulos
Seyedeh Neda Mousavy-Gharavy
Ana Guerrero
Mamunur Rashid
Nital Jani
Colin R. Goding
Thomas S. Jacques
David J. Adams
Jesus Gil
Cynthia L. Andoniadou
Juan Pedro Martinez-Barbera
spellingShingle Jose Mario Gonzalez-Meljem
Scott Haston
Gabriela Carreno
John R. Apps
Sara Pozzi
Christina Stache
Grace Kaushal
Alex Virasami
Leonidas Panousopoulos
Seyedeh Neda Mousavy-Gharavy
Ana Guerrero
Mamunur Rashid
Nital Jani
Colin R. Goding
Thomas S. Jacques
David J. Adams
Jesus Gil
Cynthia L. Andoniadou
Juan Pedro Martinez-Barbera
Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
Nature Communications
author_facet Jose Mario Gonzalez-Meljem
Scott Haston
Gabriela Carreno
John R. Apps
Sara Pozzi
Christina Stache
Grace Kaushal
Alex Virasami
Leonidas Panousopoulos
Seyedeh Neda Mousavy-Gharavy
Ana Guerrero
Mamunur Rashid
Nital Jani
Colin R. Goding
Thomas S. Jacques
David J. Adams
Jesus Gil
Cynthia L. Andoniadou
Juan Pedro Martinez-Barbera
author_sort Jose Mario Gonzalez-Meljem
title Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
title_short Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
title_full Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
title_fullStr Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
title_full_unstemmed Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
title_sort stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description Senescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation in an in vivo model of adamantinomatous craniopharyngioma.
url https://doi.org/10.1038/s41467-017-01992-5
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