Effects of Liraglutide on endothelial function, immune function and related factors in patients with type 2 diabetes mellitus
Objective: To investigate the effects of Liraglutide on endothelial function, immune function and related factors in patients with type 2 diabetes mellitus. Methods: A total of 160 patients with type 2 diabetes mellitus who received treatment in department of endocrinology of our hospital from De...
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doaj-a0493dfe699a48ed98554bd4037028ab2020-11-25T02:02:21ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372019-02-012532730Effects of Liraglutide on endothelial function, immune function and related factors in patients with type 2 diabetes mellitusDe-Zhi Bian0Yan-Mei Liu1Department of Endocrinology, Yancheng First People’s HospitalDepartment of Endocrinology, Yancheng First People’s HospitalObjective: To investigate the effects of Liraglutide on endothelial function, immune function and related factors in patients with type 2 diabetes mellitus. Methods: A total of 160 patients with type 2 diabetes mellitus who received treatment in department of endocrinology of our hospital from December 2015 to June 2018 were collected. They were randomly divided into the control group and the observation group, 80 cases in each group. The patients in the control group were treated with metformin. The patients in the observation group were treated with liraglutide on the basis of the control group. The levels of endothelin (ET-1), nitric oxide (NO), immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin G (IgG), hypersensitive C-reactive protein (hs-CRP), insulin-like growth factor-1 (IGF-1), tumor necrosis factor-α (TNF- 毩), Vaspin and HbAlc were detected and compared. Results: After treatment, compared with the treatment group, the serum levels of ET-1, hs-CRP, IGF-1, TNF-毩 and HbAlc of patients in the control group and the observation group were significantly decreased, and the levels of NO, IgA, IgG, IgM and Vaspin increased significantly. The change trend of the above indexes of patients in the observation group was more obvious than those in the control group (P<0.05). Conclusion: Liraglutide combined with metformin in the treatment of type 2 diabetes mellitus can significantly enhance endothelial function and immune function of patients, and alleviate inflammation, and it has good clinical efficacy.http://www.hnykdxxb.com/PDF/201903/07.pdf |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
De-Zhi Bian Yan-Mei Liu |
spellingShingle |
De-Zhi Bian Yan-Mei Liu Effects of Liraglutide on endothelial function, immune function and related factors in patients with type 2 diabetes mellitus Journal of Hainan Medical University |
author_facet |
De-Zhi Bian Yan-Mei Liu |
author_sort |
De-Zhi Bian |
title |
Effects of Liraglutide on endothelial function, immune function and related factors in patients with type 2 diabetes mellitus |
title_short |
Effects of Liraglutide on endothelial function, immune function and related factors in patients with type 2 diabetes mellitus |
title_full |
Effects of Liraglutide on endothelial function, immune function and related factors in patients with type 2 diabetes mellitus |
title_fullStr |
Effects of Liraglutide on endothelial function, immune function and related factors in patients with type 2 diabetes mellitus |
title_full_unstemmed |
Effects of Liraglutide on endothelial function, immune function and related factors in patients with type 2 diabetes mellitus |
title_sort |
effects of liraglutide on endothelial function, immune function and related factors in patients with type 2 diabetes mellitus |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2019-02-01 |
description |
Objective: To investigate the effects of Liraglutide on endothelial function, immune function
and related factors in patients with type 2 diabetes mellitus. Methods: A total of 160 patients
with type 2 diabetes mellitus who received treatment in department of endocrinology of our
hospital from December 2015 to June 2018 were collected. They were randomly divided into
the control group and the observation group, 80 cases in each group. The patients in the control
group were treated with metformin. The patients in the observation group were treated with
liraglutide on the basis of the control group. The levels of endothelin (ET-1), nitric oxide (NO),
immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin G (IgG), hypersensitive
C-reactive protein (hs-CRP), insulin-like growth factor-1 (IGF-1), tumor necrosis factor-α (TNF-
毩), Vaspin and HbAlc were detected and compared. Results: After treatment, compared with
the treatment group, the serum levels of ET-1, hs-CRP, IGF-1, TNF-毩 and HbAlc of patients
in the control group and the observation group were significantly decreased, and the levels of
NO, IgA, IgG, IgM and Vaspin increased significantly. The change trend of the above indexes
of patients in the observation group was more obvious than those in the control group (P<0.05).
Conclusion: Liraglutide combined with metformin in the treatment of type 2 diabetes mellitus
can significantly enhance endothelial function and immune function of patients, and alleviate
inflammation, and it has good clinical efficacy. |
url |
http://www.hnykdxxb.com/PDF/201903/07.pdf |
work_keys_str_mv |
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