Enhanced Absorption and Growth Inhibition with Amino Acid Monoester Prodrugs of Floxuridine by Targeting hPEPT1 Transporters

Enhanced Absorption and Growth Inhibition with Amino Acid Monoester Prodrugs of Floxuridine by Targeting hPEPT1 Transporters

A series of amino acid monoester prodrugs of floxuridine was synthesized and evaluated for the improvement of oral bioavailability and the feasibility of target drug delivery via oligopeptide transporters. All floxuridine 5′-amino acid monoester prodrugs exhibited PEPT1 affinity, with inhibitio...

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Bibliographic Details
Main Authors: Gordon L. Amidon, Chandrasekharan Ramachandran, John M. Hilfinger, Christopher P. Landowski, Jing Sun, Balvinder S. Vig, Yasuhiro Tsume
Format: Article
Language:English
Published: MDPI AG 2008-06-01
Series:Molecules
Subjects:
5-FU
floxuridine
prodrugs
Caco-2 permeability
cell proliferation assays
oligopeptide transporter 1 (PEPT1)
Online Access:http://www.mdpi.com/1420-3049/13/7/1441/

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