Sex-specific urinary biomarkers for diagnosing bipolar disorder.
Sex-based differences are prominent in affective disorders, but there are no biomarkers available to support sex-specific, laboratory-based diagnostics for male and female bipolar disorder (BD) patients. Here, a NMR-based metabonomic approach was used to preliminarily identify sex-specific urinary m...
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doaj-a04e02b73c9e4467a4ab45f696cb6a452020-11-24T21:42:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11522110.1371/journal.pone.0115221Sex-specific urinary biomarkers for diagnosing bipolar disorder.Jian-jun ChenHua HuangLi-bo ZhaoDe-zhi ZhouYong-tao YangPeng ZhengDe-yu YangPeng HeJing-jing ZhouLiang FangPeng XieSex-based differences are prominent in affective disorders, but there are no biomarkers available to support sex-specific, laboratory-based diagnostics for male and female bipolar disorder (BD) patients. Here, a NMR-based metabonomic approach was used to preliminarily identify sex-specific urinary metabolite biomarkers for diagnosing male and female BD patients. A male-specific biomarker panel consisting of four metabolites (α-hydroxybutyrate, choline, formate, and N-methylnicotinamide) effectively discriminated between male BD and healthy controls (HC) subjects, achieving an area under the receiver operating characteristic curve (AUC) of 0.942. A female-specific biomarkers panel consisting of four metabolites (α-hydroxybutyrate, oxalacetate, acetone, and N-methylnicotinamide) effectively discriminated between female BD and HC subjects, achieving an AUC of 0.909. The male-specific biomarker panel displayed low discriminatory power in the female group, and the female-specific biomarker panel displayed low discriminatory power in the male group. Moreover, several other metabolites showed different trends between male and female BD subjects. These findings suggest that male and female BD patients have distinct biomarker fingerprints and that these two sex-specific biomarker panels may serve as effective diagnostic tools in distinguishing male and female BD patients from their healthy counterparts. Our work may provide a window into the mechanisms underlying the pathoetiology of BD in both men and women.http://europepmc.org/articles/PMC4274077?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jian-jun Chen Hua Huang Li-bo Zhao De-zhi Zhou Yong-tao Yang Peng Zheng De-yu Yang Peng He Jing-jing Zhou Liang Fang Peng Xie |
spellingShingle |
Jian-jun Chen Hua Huang Li-bo Zhao De-zhi Zhou Yong-tao Yang Peng Zheng De-yu Yang Peng He Jing-jing Zhou Liang Fang Peng Xie Sex-specific urinary biomarkers for diagnosing bipolar disorder. PLoS ONE |
author_facet |
Jian-jun Chen Hua Huang Li-bo Zhao De-zhi Zhou Yong-tao Yang Peng Zheng De-yu Yang Peng He Jing-jing Zhou Liang Fang Peng Xie |
author_sort |
Jian-jun Chen |
title |
Sex-specific urinary biomarkers for diagnosing bipolar disorder. |
title_short |
Sex-specific urinary biomarkers for diagnosing bipolar disorder. |
title_full |
Sex-specific urinary biomarkers for diagnosing bipolar disorder. |
title_fullStr |
Sex-specific urinary biomarkers for diagnosing bipolar disorder. |
title_full_unstemmed |
Sex-specific urinary biomarkers for diagnosing bipolar disorder. |
title_sort |
sex-specific urinary biomarkers for diagnosing bipolar disorder. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
Sex-based differences are prominent in affective disorders, but there are no biomarkers available to support sex-specific, laboratory-based diagnostics for male and female bipolar disorder (BD) patients. Here, a NMR-based metabonomic approach was used to preliminarily identify sex-specific urinary metabolite biomarkers for diagnosing male and female BD patients. A male-specific biomarker panel consisting of four metabolites (α-hydroxybutyrate, choline, formate, and N-methylnicotinamide) effectively discriminated between male BD and healthy controls (HC) subjects, achieving an area under the receiver operating characteristic curve (AUC) of 0.942. A female-specific biomarkers panel consisting of four metabolites (α-hydroxybutyrate, oxalacetate, acetone, and N-methylnicotinamide) effectively discriminated between female BD and HC subjects, achieving an AUC of 0.909. The male-specific biomarker panel displayed low discriminatory power in the female group, and the female-specific biomarker panel displayed low discriminatory power in the male group. Moreover, several other metabolites showed different trends between male and female BD subjects. These findings suggest that male and female BD patients have distinct biomarker fingerprints and that these two sex-specific biomarker panels may serve as effective diagnostic tools in distinguishing male and female BD patients from their healthy counterparts. Our work may provide a window into the mechanisms underlying the pathoetiology of BD in both men and women. |
url |
http://europepmc.org/articles/PMC4274077?pdf=render |
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