Colorectal Cancer & Molecular Mutations and Polymorphism

Colorectal Cancer & Molecular Mutations and Polymorphism

Colorectal cancer (CRC) is one of the major causes of mortality and morbidity, and is the third most common cancer in men and the second most common cancer in women worldwide. The incidence of CRC shows considerable variation among racially or ethnically defined populations in multiracial/ethnic cou...

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Bibliographic Details
Main Author: Aga Syed Sameer
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-05-01
Series:Frontiers in Oncology
Subjects:
Genetics, Medical
colorectal cancer
mutations
polymorphism
hypermethylation
Kashmir
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00114/full
Description
Summary:Colorectal cancer (CRC) is one of the major causes of mortality and morbidity, and is the third most common cancer in men and the second most common cancer in women worldwide. The incidence of CRC shows considerable variation among racially or ethnically defined populations in multiracial/ethnic countries. The tumorigenesis of CRC is either because of the chromosomal instability (CIN) or microsatellite instability (MIN) or involving various proto-oncogenes, tumor suppressor genes and also epigenetic changes in the DNA. In this review I have focused on the mutations and polymorphisms of various important genes of the CIN and MIN pathways which have been implicated in the development of CRC.
ISSN:2234-943X

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