Colorectal Cancer & Molecular Mutations and Polymorphism

Colorectal Cancer & Molecular Mutations and Polymorphism

Colorectal cancer (CRC) is one of the major causes of mortality and morbidity, and is the third most common cancer in men and the second most common cancer in women worldwide. The incidence of CRC shows considerable variation among racially or ethnically defined populations in multiracial/ethnic cou...

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Main Author: Aga Syed Sameer
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-05-01
Series:Frontiers in Oncology
Subjects:
Genetics, Medical
colorectal cancer
mutations
polymorphism
hypermethylation
Kashmir
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00114/full
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spelling doaj-a05237acdbc74bbd8379e12c4ca005142020-11-25T00:36:37ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2013-05-01310.3389/fonc.2013.0011438942Colorectal Cancer & Molecular Mutations and PolymorphismAga Syed Sameer0SKIMS Medical CollegeColorectal cancer (CRC) is one of the major causes of mortality and morbidity, and is the third most common cancer in men and the second most common cancer in women worldwide. The incidence of CRC shows considerable variation among racially or ethnically defined populations in multiracial/ethnic countries. The tumorigenesis of CRC is either because of the chromosomal instability (CIN) or microsatellite instability (MIN) or involving various proto-oncogenes, tumor suppressor genes and also epigenetic changes in the DNA. In this review I have focused on the mutations and polymorphisms of various important genes of the CIN and MIN pathways which have been implicated in the development of CRC.http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00114/fullGenetics, Medicalcolorectal cancermutationspolymorphismhypermethylationKashmir
collection DOAJ
language English
format Article
sources DOAJ
author Aga Syed Sameer
spellingShingle Aga Syed Sameer
Colorectal Cancer & Molecular Mutations and Polymorphism
Frontiers in Oncology
Genetics, Medical
colorectal cancer
mutations
polymorphism
hypermethylation
Kashmir
author_facet Aga Syed Sameer
author_sort Aga Syed Sameer
title Colorectal Cancer & Molecular Mutations and Polymorphism
title_short Colorectal Cancer & Molecular Mutations and Polymorphism
title_full Colorectal Cancer & Molecular Mutations and Polymorphism
title_fullStr Colorectal Cancer & Molecular Mutations and Polymorphism
title_full_unstemmed Colorectal Cancer & Molecular Mutations and Polymorphism
title_sort colorectal cancer & molecular mutations and polymorphism
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2013-05-01
description Colorectal cancer (CRC) is one of the major causes of mortality and morbidity, and is the third most common cancer in men and the second most common cancer in women worldwide. The incidence of CRC shows considerable variation among racially or ethnically defined populations in multiracial/ethnic countries. The tumorigenesis of CRC is either because of the chromosomal instability (CIN) or microsatellite instability (MIN) or involving various proto-oncogenes, tumor suppressor genes and also epigenetic changes in the DNA. In this review I have focused on the mutations and polymorphisms of various important genes of the CIN and MIN pathways which have been implicated in the development of CRC.
topic Genetics, Medical
colorectal cancer
mutations
polymorphism
hypermethylation
Kashmir
url http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00114/full
work_keys_str_mv AT agasyedsameer colorectalcancerampmolecularmutationsandpolymorphism
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